Reviews & Commentaries

Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer.
Halbrook CJ, Wahl DW, Lyssiotis CA. Trends in Biochemical Sciences (2019) 44:991–993
Abstract

The Metabolic Regulation of Redox Balance in Cancer.
Purohit V, Simeone D, Lyssiotis CA. Cancers (2019) 11:7.
Abstract | PDF

New tricks for an old drug.
Nelson BS, Kremer DM, Lyssiotis CA. Nat Chem Biol (2018) [Epub ahead of print].
Abstract

Metabolism and Epigenetics of Pancreatic Cancer Stem Cells
Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. Semin Cancer Biol (2018) [Epub ahead of print].
Abstract
 
The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC. Pancreas (2018) 47:516-525.
Abstract

Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation
Halbrook CJ, Nwosu ZC, Lyssiotis CA. Trends Endocrinol Metab (2018) 29:599-602.
Abstract

Tumor Crosstalk Networks Promote Growth and Support Immune Evasion in Pancreatic Cancer
Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. Am J Physiol Gastrointest Liver Physiol (2018) 315:G27-G35.
Abstract

When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade 
Shan M, Lyssiotis CA. Cell Metabolism (2017) 26:811–813.
Abstract

A Topical Report on the Design Principles of Metabolism
Halbrook CJ, Lee HJ, Cantley LC, Lyssiotis CA. Imaging and Metabolism, Springer, Cham, (2018) 29-44.
Abstract

Metabolic Interactions in the Tumor Microenvironment
Lyssiotis CA, Kimmelman AC. Trends in Cell Biology (2017) 27:863-875.
Abstract

Emerging roles for SIRT5 in metabolism and cancer
Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Antioxid Redox Signal. (2017) 28:677-90.
Abstract

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook CJ, Lyssiotis CA. Cancer Cell (2017) 31:5-19.
Abstract

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant Kras-Driven Cancers
Shah Y, Lyssiotis CA. Gastroenterology (2016) 151:798-801.
Abstract

A Novel Small-Molecule Inhibitor of 3-Phosphoglycerate Dehydrogenase
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. Molecular and Cellular Oncology (2016) 3:e1164280.
Abstract

Metabolic Reprogramming by the PI3K/AKT-mTOR Pathway in Cancer
Lien E, Lyssiotis CA, Cantley LC. In: Recent Results in Cancer Research. Metabolism in Cancer. New York, NY. Springer Publishing Group. Kramer T, Schmitt CA. eds. (2016) 207:39–72.
Abstract

Designing a Broad-Spectrum Integrative Approach for Cancer Prevention and Treatment
Getting to Know Cancer Taskforce*. [*member of >200 author taskforce] Seminars in Cancer Biology (2015) 35S, S276–S304.
Abstract

Dysregulated Metabolism Contributes to Oncogenesis
Hirschey MD, *DeBerardinis RJ, *Diehl AME, *Drew J, *Frezza C, *Green MF, *Jones LW, *Ko YH, *Le A, *Lea MA, *Locasale JW, *Longo VD, *Lyssiotis CA, *McDonnell E, *Mehrmohamadi M, *Michelotti G, *Muralidhar V, *Murphy MP, *Pedersen P, *Poore B, *Raffaghello L, *Rathmell JC, *Sivanand S, *Vander Heiden MG, *Wellen KE; Target Validation Team. [*equal contribution; authors listed alphabetically] Semin Cancer Biol (2015) 35S, S129–S150.
Abstract

Acetate Fuels the Cancer Engine
Lyssiotis CA, Cantley LC. Cell (2014) 159, 1492–1494.
Abstract

Fluxing Through Cancer: Tracking the Fate of 13C-Labeled Energy Sources in Cancer Cells and Mouse Tumors
Lyssiotis CA, Breitkopf SB, Yuan M, Bellinger G, Asara JM. Cambridge Isotope Labs (2014) Application Note 34.
PDF

Targeting Metabolic Scavenging in Pancreatic Cancer
Lyssiotis CA, Cantley LC. Clinical Cancer Research (2014) 20, 6–8.
Abstract

Metabolic Syndrome: F Stands for Fructose and Fat
Lyssiotis CA, Cantley LC. Nature (2013) 502, 181–182.
Abstract | Press

Pancreatic Cancers Rely on a Novel Glutamine Metabolism Pathway to Maintain Redox Balance
Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Cell Cycle (2013) 12, 1987–1988.
Abstract

SIRT6 Puts Cancer Metabolism in the Driver’s Seat
Lyssiotis CA, Cantley LC. Cell (2012) 151, 1155-1156.
Abstract

Small Molecule-Based Approaches to Adult Stem Cell Therapies
Lairson LL, Lyssiotis CA, Zhu S & Schultz PG. Annual Review of Pharmacology and Toxicology (2013) 6, 107–125.
Abstract | PDF

Emerging Concepts: Linking Hypoxic Signaling and Cancer Metabolism
Lyssiotis CA, Vander Heiden MG, Muñoz-Pinedo C, Emerling BM. Cell Death and Disease (2012) 3, e303.
Abstract

Cellular Control Mechanisms that Regulate Pyruvate Kinase M2 Activity and Promote Cancer Growth
Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Biomed Research (2012) 23, 213–217.

Chemical Control of Stem Cell Fate and Developmental Potential
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Angewandte Chemie (2011) 50, 200–242.
Abstract | German | Times cited: 154

Insight into the Reprogramming of Cell Fate with Small Molecules
Lyssiotis CA. Graduate Thesis (2010).

Reprogramming Developmental Potential
Lyssiotis CA, Charette BD & Lairson LL. In: Emerging Technology Platforms for Stem Cells (2009) New York, NY. John Wiley & Sons Press, Inc.; 51–85. Lakshmipathy U, Chesnut JD & Thyagarajan B, eds.

Cautiously Interpret Data
Lyssiotis CA. Chemical & Engineering News (2007) Nov-12, 6.
Article