Singh Lab Publications

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Key Publications

Explore significant publications from the Singh lab.
  1. A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome.
    Deng K, Wang Y, Min JC, Liu X, Myers G, Yu L, Hammoud S, Adam A, Saba R, Natogi V, Drysdale C, Chen B, Ueharu H, Yee JL, Kitzman J, Lyssiotis CA, Mishina Y, Jones M, Kaartinen V, Guan Y, Khoriaty R, Engel JD,Singh SA.
    bioRxiv [Preprint]. 2025 May 27:2025.05.22.654334. doi: 10.1101/2025.05.22.654334.
    PMID: 40502144
  2. Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model.
    Wang Y, Yu L, Deng K, Packiarajan M, Aguilar A, An S, Liu X, Myers G, Oh H,Singh SA, Cho US, Wang S, Guan Y, White AD, Khoriaty R, Engel JD.
    Blood. 2025 Jul 17;146(3):356-368. doi: 10.1182/blood.2024028006.
    PMID: 40332031
  3. A genome-wide screen identifies genes required for erythroid differentiation.
    Myers G, Friedman A, Yu L, Pourmandi N, Kerpet C, Ito MA, Saba R, Tang V, Ozel AB, Bergin IL, Johnson CN, Ku CJ, Wang Y, Balbin-Cuesta G, Lim KC, Lin Z, Drysdale C, McGee B, Kurita R, Nakamura Y, Liu X, Siemieniak D,Singh SA, Lyssiotis CA, Maillard I, Weisman LS, Engel JD, Khoriaty R.
    Nat Commun. 2025 Apr 12;16(1):3488. doi: 10.1038/s41467-025-58739-w.
    PMID: 40221460
  4. TR4 and BCL11A repress γ-globin transcription via independent mechanisms.
    Wang Y, Myers G, Yu L, Deng K, Balbin-Cuesta G,Singh SA, Guan Y, Khoriaty R, Engel JD.
    Blood. 2024 Dec 26;144(26):2762-2772. doi: 10.1182/blood.2024024599.
    PMID: 39393056
  5. Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions.
    Myers G, Wang Y, Wang Q, Friedman A, Sanchez-Martinez A, Liu X,Singh SA, Lim KC, Khoriaty R, Engel JD, Yu L.
    Blood Adv. 2023 Oct 10;7(19):5727-5732. doi: 10.1182/bloodadvances.2023010088.
    PMID: 37552129
  6. Identification of novel γ-globin inducers among all potential erythroid druggable targets.
    Yu L, Myers G, Schneider E, Wang Y, Mathews R, Lim KC, Siemieniak D, Tang V, Ginsburg D, Balbin-Cuesta G,Singh SA, Phuwakanjana P, Jearawiriyapaisarn N, Khoriaty R, Engel JD.
    Blood Adv. 2022 Jun 14;6(11):3280-3285. doi: 10.1182/bloodadvances.2021006802.
    PMID: 35240686
  7. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia.
    Yu L, Lemay P, Ludlow A, Guyot MC, Jones M, Mohamed FF, Saroya GA, Panaretos C, Schneider E, Wang Y, Myers G, Khoriaty R, Li Q, Franceschi R, Engel JD, Kaartinen V, Rothstein TL, Justice MJ, Kibar Z,Singh SA.
    Blood Adv. 2021 Oct 26;5(20):4167-4178. doi: 10.1182/bloodadvances.2021004658.
    PMID: 34464976
  8. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation.
    Yu L, Myers G, Ku CJ, Schneider E, Wang Y,Singh SA, Jearawiriyapaisarn N, White A, Moriguchi T, Khoriaty R, Yamamoto M, Rosenfeld MG, Pedron J, Bushweller JH, Lim KC, Engel JD.
    Blood. 2021 Nov 4;138(18):1691-1704. doi: 10.1182/blood.2021011682.
    PMID: 34324630