Adaptive Immunity
At the University of Michigan Medical School Department of Microbiology & Immunology, we study the basic questions relating to the role of T and B lymphocytes in adaptive immunity. Many of us seek to understand adaptive immunity at a molecular level in whole animals. These studies provide important insights into the function of the adaptive immune system in health and disease.
Learn more below about our areas of investigation and view a list of faculty members conducting research on adaptive immunity.
Department News
What we do in M&I: Adaptive Immunology
Areas of Investigation
We investigate:
- Intracellular signaling mechanisms regulating T cell development and activation
- Immunoglobulin class switch recombination in B cells using techniques such as bacterial artificial chromosome transgenesis
- The behavior of T cells as regulators of adaptive immune responses and as effector cells is examined in bacterial infection and organ transplantation models using combined cellular and molecular approaches.
- The mechanisms involved in processing of antigen for recognition by T cells, including intracellular assembly of major histocompatibility complex class I proteins, and their altered trafficking in virus-infected cells
We are using the latest techniques and technology, including genome engineering methods.
Faculty researching Adaptive Immunity
Michael Bachman, MD, PhD
Clinical Professor of Pathology
Clinical Professor of Microbiology and Immunology
Program Director, Clinical Research, Clinical Pathology Division, Medical School
Clinical Professor of Microbiology and Immunology
Program Director, Clinical Research, Clinical Pathology Division, Medical School
Cheong-Hee Chang, PhD
Professor of Microbiology and Immunology, Medical School
Kathleen Collins, MD, PhD
Professor of Internal Medicine
Professor of Microbiology and Immunology
Associate Dean for Physician Scientist Education and Training, Medical School
Professor of Microbiology and Immunology
Associate Dean for Physician Scientist Education and Training, Medical School
Philip D King, PhD
Professor of Microbiology and Immunology, Medical School
Denise E Kirschner, PhD
Professor of Microbiology and Immunology, Medical School
Yasmina Laouar, PhD
Associate Professor of Microbiology and Immunology, Medical School
Bethany Moore, PhD
Nancy Walls Professor of Microbiology and Immunology
Chair, Department of Microbiology and Immunology
Professor of Microbiology and Immunology
Professor of Internal Medicine, Medical School
Chair, Department of Microbiology and Immunology
Professor of Microbiology and Immunology
Professor of Internal Medicine, Medical School
Michal A Olszewski, DVM, PhD
Professor of Internal Medicine
Professor of Microbiology and Immunology
Associate Director Academic Program, Immunology Graduate Program, Medical School
Professor of Microbiology and Immunology
Associate Director Academic Program, Immunology Graduate Program, Medical School
Jeffrey L Platt, MD
Professor Emeritus/A of Surgery
Professor Emeritus of Microbiology and Immunology, Medical School
Professor Emeritus of Microbiology and Immunology, Medical School
Malini Raghavan, PhD
Nancy Walls Research Professor of Microbiology and Immunology
Professor of Microbiology and Immunology, Medical School
Professor of Microbiology and Immunology, Medical School
Anukul Shenoy, PhD
Assistant Professor of Microbiology and Immunology, Medical School
