Research | Judith Tam ALK Lung Cancer Research Initiative

Dr. Sofia Merajver with a post-doctoral fellow

Projects Powering Discovery and Innovation

At the heart of the Judith Tam ALK Lung Cancer Research Initiative is a passion for discovery and a commitment to making a meaningful impact on the lives of people affected by ALK+ lung cancer. Our research portfolio spans basic science, translational studies, and clinical innovation—each project designed to answer pressing questions, develop better therapies, and improve outcomes. Explore our active, developing, and past research projects below. Each project listing links to more detailed information, including project aims, leadership, publications, and recent news.

 

Browse Our Projects

zackariah_farah_uv_agarose_gel_electrophoresis_analysis

Project 1

Understanding Efficacy and Resistance in ALK NSCLC Through Tumor Organoid Drug Testing and Multi-omic Integration

Learn more about Project 1
Nrf2-3_SPC_CD31_CC10_40X-1

Project 2

Modeling and Characterizing Early ALK-dependent Tumorigenesis

Learn more about Project 2
A lab technician wearing gloves is using a micropipette to load samples into a PCR plate

Project 3

Pursuing New Approaches to Invent and Test a New Strategy for Using Combinations of Drugs Against ALK and Create Novel Inhibitors Against ALK, by Targeting a Portion of the ALK Molecule Not Usually Targeted by Conventional Therapies

Learn more about Project 3
multiplex immunofluorescence / spatial imaging composite of lung tumor tissue

Developing Projects

Explore our pipeline of developing projects—each designed to push the boundaries of understanding, prevention, detection, and treatment of lung cancer.

Learn more about our Developing Projects
ananya-banerjee-blood-sample-processing

Past Projects

Our journey toward better lung cancer outcomes is built on a foundation of collaboration, discovery, and progress.

Learn more about our Past Projects

Our collaborators

Advancing meaningful research is a team effort, and we are deeply grateful to our valued collaborators whose expertise and partnership accelerate progress in ALK+ lung cancer research. Together, we are pushing boundaries, sharing knowledge, and making a greater impact for patients and families.

We extend special thanks to our notable collaborators:

GenPrex

Advancing novel gene therapies and translational approaches for lung cancer treatment.

Genprex is honored to have an active and productive collaboration with the Judith Tam ALK Lung Cancer Research Initiative.  Through this partnership, our company has been able to conduct important and successful preclinical research that opens the door for a new clinical trial that of quaratusugene ozeplasmid (REQORSA) and seeks to offer additional treatment options for patients with ALK rearrangements.” 

– Dr. Mark Berger, MD, Chief Medical Officer for Genprex


Seoul National University

Providing cutting-edge clinical insights, international collaboration, and vital tissue samples—directly supporting our work in modeling and characterizing early ALK-dependent tumorigenesis.


ALK Positive Summit

Empowering the patient community and accelerating research through advocacy, engagement, and support.


We thank each of our collaborators for their dedication and partnership. Together, we are making a real difference in the fight against ALK+ lung cancer.

News and Stories

man dirt biking jumping hill in woods
Health Lab

Doctor helps one father’s race against lung cancer

Successful treatment of ALK-positive cancer is giving a patient hope for the future that includes trips around the motocross track and time with his wife and four kids.
Department News

ALK Positive Summit Blood Collection

Team members of the Judith Tam ALK Lung Cancer Research Initiative ventured out to Nashville on July 18th for the 2024 ALK Positive Summit, to embark on an unprecedented research blood collection which took place July 19th and 20th.
News Release

$7.6 million gift launches new lung cancer research initiative at U-M

Increased understanding of the genetic mutations that drive non-small cell lung cancer has led to new, effective treatments in recent years.
scientists in goggles gloves looking at specimen in lab
Health Lab

Changing the treatment of cancer

Breakthroughs in the field of genomics are revolutionizing prevention, diagnosis and care.
Medicine at Michigan

Professorships

Professorships recently inaugurated