Explore the research resources available at NCRC.
Multiple scientific resources are located at NCRC including the many Biomedical Research Core Facilities, Imaging Cores, the Biorepository and much more. Together, they work to facilitate the infrastructure improvements that benefit the entire research enterprise and leverage resources to support investigator-driven science.
The Pharmacokinetics (PK) Core facility is a shared resource aimed at providing drug metabolism preclinical PK (DMPK), clinical pharmacokinetic and population pharmacokinetic services for the research community. The PK Core offers an array of services to support lead optimization and dose translation. These services include:
- LC-MS assay development
- Microsomal stability
- Metabolite identification
- Permeability
- Protein binding
- Preclinical PK
- Clinical PK
- Non-compartmental, Compartmental, Population PK analyses
Our mission is to facilitate interdisciplinary researchers' efforts to discover new medicines, obtain research funding, file patent applications, and publish academic research findings for both preclinical and clinical pharmacokinetic applications.
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Bo Wen, Core Manager
Phone: 734-615-3470
Bioinformatics is the development and application of computational tools and methods to biological or biomedical research data including acquisition, storage, organization analysis or visualization of data.
What We Do
Bioinformatics Analysis – We work with research scientists (faculty, staff, post-docs and graduate students) to provide analysis of their high-throughput sequencing, gene expression, metabolomics, proteomics, and other biological data.
Consulting prior to experiments – We will meet with you to discuss the types of analysis and support bioinformatics can provide and help design experiments so that analysis is possible. We can help with grant proposals to incorporate bioinformatics data analysis in your research plan. This also demonstrates that we have the capability to perform the analysis. We will also prepare letters of support for your proposal.
Data analysis for genome resequencing, ChIP-Seq transcription factor analysis, RNA-Seq analysis, de novo assembly, metagenomic sequencing, and gene set enrichment analysis. We perform the analysis and meet with you to report back the results.
Application development – help develop custom applications to enhance research through web applications for data analysis, custom pipelines, databases and/or visualization, and web services interfaces to large databases, and custom analysis tools.
Training – Although not currently deployed, we will be developing training programs to assist researchers in learning the computational tools that can be translated back to their labs.
Participate in the Bioinformatics Core Customer Survey & You Could Win!
To better meet the needs of our customers, the Bioinformatics Core is conducting a survey to allow users an opportunity to provide feedback.
Take our five-minute customer survey
The time you spend completing this survey will help us bring you the services you and your lab need for future success. To thank you for sharing your thoughts and feedback with us, we will be giving away $25 Target gift cards, laptop cases and other prizes. To enter the prize drawing, please include your name and email in the survey.
Thank you for taking time from your busy day to provide us with valuable feedback.
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Consultation or service:
[email protected]
Applying to the graduate program:
[email protected]
The Biomedical Research Core Facilities (BRCF) are part of the University of Michigan Medical School Office of Research. They enable cutting-edge research by helping researchers economically and efficiently take advantage of the latest technology and collaborate with top experts in the field.
They continually evaluate the technology and service needs of researchers, coordinate applications for grants to purchase equipment, and offer comprehensive training for investigators; many of the Cores offer their services to other research institutions and the private sector. The BRCF are among the top enablers in the Medical School's Strategic Research Initiative. They work together to facilitate the infrastructure improvements that benefit the entire research enterprise and leverage resources to support investigator-driven science. To learn more about recent strategic investments made into the Cores, visit the investments page.
Serving the entire University of Michigan research enterprise, the BRCF aims to provide our customers with economical, efficient services of the highest quality with the ultimate goal of positively impacting human health.
The Biomedical Research Store is part of the Biomedical Research Core Facilities in the Office of Research. The Store provides University of Michigan research investigators with easy, on-site procurement of enzymes, reagents, and kits used in molecular, cell biology, and some protein chemistry. More than 700 different items from 11 vendors are stocked at five locations for immediate purchase. Our large-volume vendor contracts enable the Store to negotiate very low prices as well as eliminate all shipping and packaging fees. Vendors that currently have contracts with the Store are:
- Agilent
- Akadeum Life Sciences
- BioRad
- Corning
- Finnzymes
- Invitrogen-(Applied Biosystems)/Life Technologies
- Lonza
- New England Biolabs
- Pierce
- Promega
- Qiagen
- Roche Applied Science
- Sigma
Stocked inventory varies from location to location, and thousands of items that are not stocked are available by special order and generally available the next day.
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Christina Stilson
Manager, Biomedical Research Store
Phone: 734-936-2870
If you would like to know whether we have a certain item available, or to receive the most up-to-date list of stocked items, please inquire directly with:
- Biomedical Sciences Research Building (BSRB): 734-615-6072
- Brehm Tower: 734-232-8206
- Life Sciences Institute (LSI): 734-615-5701
- Medical Science Research Building II (MSRB II): 734-615-5447 or 734-936-7626
- North Campus Research Complex (NCRC Building 14): 734-615-2601
Location Hours:
Monday-Friday: 8:15 a.m.-12:15 p.m. and 1:15 p.m.-5:00 p.m.
As part of the Medical School's Strategic Research Initiative, the Central Biorepository will enhance the full spectrum of our research portfolio by providing a world-class, accredited, standardized, safe and monitored environment for the processing, storage and distribution of high-quality normal and diseased biospecimens annotated with detailed clinical and laboratory data.
The Central Biorepository is still in early implementation stages, establishing a facility at the North Campus Research Complex (NCRC). The development plan recommended by the faculty experts and outside consultants involves the setup of four Pilot Projects for initialization of the biorepository operation, and the establishment of procedures for onboarding new studies into the repository.
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CBR Business Operations
[email protected]
Phone: 734-647-8809
The Flow Cytometry Core provides instrumentation and expertise to University of Michigan investigators — and the surrounding biotech community — in a broad range of basic and medical science disciplines. Samples are prepared by individual investigators, who then deliver samples to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and development of experimental designs.
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David Adams
Manager, Flow Cytometry Core
Phone: 734-764-8107
The In-Vivo Pathology Core (formerly IVAC), part of the Unit for Laboratory Animal Medicine (ULAM), serves as a fee-for-service resource supporting pre-clinical and translational research. Using University resources and accomplished ULAM professionals specializing in diverse fields, IVAC optimizes the design, execution, interpretation, and reporting of in-vivo studies to guide projects through early translational milestones. Services that can be utilized individually or combined as a full service based on the needs of your research project include:
- Pre-clinical project consultation and study design
- Animal diagnostic laboratory testing
- In-vivo animal handling, including blood collection and test article dosing
- Necropsy, histology, and immunohistochemistry preparations
- Digital slide scanning
- Clinical pathology and anatomic pathology evaluation and reporting
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For additional information, or to set up an appointment to consult with us on your pre-clinical research designs, please contact us at [email protected] or 734-647-0731.
Liquid Scintillation Counter for researcher’s use at NCRC.
If you want to use the LS counter, you can only gain access to the equipment room and use the equipment if:
- You acknowledge that you are an authorized user of RAD materials at NCRC or (work for a PI that is), and
- You perform the on-line instrument training, and
- You acknowledge via Email that you will comply with rules regarding the equipment and room usage. If you are the PI requesting access for your staff, then you ensure that your staff follows these procedures.
How to gain access to the equipment room
Request “ADDITIONAL ACCESS” to Room B20-19N on the Medical School access request form.
- Send the completed form along with the following items b, c, and d to [email protected]
- Attach to the email a note from your P.I. stating that you have attended radiation safety training at UM and are operating under his/her RSS approval number ___ (insert number). If you are the Principal Investigator requesting access for yourself, send your RSS approval number for work at NCRC.
- State in your Email that you will comply with procedures regarding equipment and room usage. If you are sending on behalf of your staff, state that you will ensure that your staff comply.
- Request in your email access and instructions regarding the online equipment training.
Procedure for Using the Room Housing the PE TriCarb LS Counter
For use only by (or staff of) authorized users of radioactive materials at NCRC.
The equipment and room was provided for researcher’s convenience. NCRC has no staff to support scientific equipment; therefore, we are conducting an “experiment” to determine if unstaffed equipment rooms can succeed here in a safe and effective way. Users’ behaviors will determine whether the “experiment” is continued or ended.
- Room 20-19N (on ground floor) is a “self-policed” shared room for the sole purpose of using the Liquid Scintillation Counter.
- Since only authorized users of radioactive materials at NCRC and their staff will be given access, this will drastically limit those who have access and are responsible for the room.
- Users must complete the equipment log legibly for each use.
- Users are accountable to each other for the equipment and room condition. (There is no one who comes in to clean up after users. There is no one who comes in and checks the machine. The user must clean up after him/herself.)
- No material of any kind may be left in the room (for example: LS vials, papers, supplies).
- If you find the room in disarray when you arrive, or equipment is not working, check the user log for the previous user and contact him/her to resolve.
- If the equipment is not operating properly, users will have to call the vendor; there is no on-site support. (See PE contact number on machine.)
- If compliance with these procedures is poor, (for example, EHS find the room contaminated during their normal spot checks, materials are left in the room, the machine is broken and no one has called to repair it), this shared support room “experiment” will be ended.
We appreciate your support as we deploy novel strategies to support YOU, the research Community.
More than 600 researchers from a variety of disciplines use the Michigan Center for Materials Characterization to precisely characterize the structure and chemical composition of materials at the nanoscale.
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Michigan Center for Materials Characterization
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Established in 1978, the Microscopy and Image Analysis Laboratory (MIL) is a centralized operation including more than 3,000 square feet housing major equipment, used on a shared basis by investigators focusing mainly on studies of cell and tissue morphology and ultrastructure. It offers state-of-the-art equipment for microscopic imaging, including fluorescence microscopy, as well as scanning and transmission electron microscopy.
The Physiology Phenotyping Core (PPC) provides state of the art phenotyping services for animal models ranging from zebrafish all the way to large animals, with a primary focus on mouse and rodent models of disease.
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ULAM provides guidance for the University’s animal care and use program campus-wide. To achieve this, our staff and faculty furnish the biomedical research community with a variety of services including laboratory animal procurement and care, veterinary care, compliance oversight and monitoring, personnel training and specialized research support cores and activities.
ULAM also has academic teaching and research programs. Our faculty conducts basic research, primarily in host-pathogen interactions, and clinical research on the biology and diseases of laboratory animals and the impact of common laboratory environmental parameters on animal physiology and behavior.
