Research Cores | MiMHC

three researchers looking at a screen

Specialized Technologies & Expertise

To accomplish our goals and to continue creating a robust and sustainable impact on the musculoskeletal community, the research cores will provide:

  • Expertise and guidance on the best use of technologies and experimental design to allow investigators to conduct specialized experiments for quantifying structure and composition across length scales.
  • Expert use, standardization, and training in state-of-the-art technologies to quantify structure and composition across physiological length scales.
  • Expertise and scientific guidance on data analysis, interpretation of results and recommendations for future studies.
  • Expand opportunities for our research community through innovation and development of enabling technologies, education, training, and enrichment.

The MiMHC supports three resource cores:

Structure, Composition & Histology Core

This core includes micro/nanoComputed Tomography, Raman spectroscopy, plastic and paraffin embedding, access to specialized equipment for sectioning and staining

Functional Assessment Core

This core includes physiological testing, microsurgery models, muscle mechanics, tendon testing, bone testing, custom fabrication/machining, fracture healing/surgical models

Integrative Data Analytics Core

This core includes imaging data analysis, Omics data analysis, statistical assessment of biological and biomedical data and integrative machine learning

For more information on MiMHC, the services from the various cores and prices, please download and read the MiMHC Core Services Handbook.

Data Sharing

Below are publications and associated data shared by researchers of the MiMHC.

Author(s): Karl J. Jepsen, PhD 

Description: Our analysis utilized data from the Bolton-Brush study, a longitudinal dataset which includes posteroanterior (PA) radiographs of the nondominant hand of White children from Cleveland, Ohio, collected around 1930. Hand radiographs from a randomly selected subgroup of those enrolled in this study were purchased from the Broadbent-Bolton Collection at the Bolton-Brush Growth Study Center. The current dataset included 45 females and 54 males who were approximately eight years old. Data included body weight and height, when available, and all morphological measures quantified from hand radiographs including metacarpal length, outer width, inner width and those derived assuming a circular cross-section (e.g., total area, cortical area, marrow area). 

Additional resources: The archived data is deidentified and publicly available from the study center (https://case.edu/dental/departments-programs/bolton-brush-growth-study-center). 

Citation(s)

Jepsen, K. J., Bredbenner, T. L., Cosman, M., Hertz, S., Klein, F. (2025). Impact of external bone size on the identification of low mass in children, using the Bolton Brush Data [Data set], University of Michigan - Deep Blue Data. https://doi.org/10.7302/47ej-xb63