Back to Functional Assessment Core

Pricing & Services Functional Assessment Core

Pricing & Services

The supported services will use the NIH P30 support to offset the staffing costs for the services below. The maximum amount of NIH P30 support available to each investigator may be capped, and therefore the number of recharged procedures that will be available at the discounted rate may be limited. Please contact the appropriate director or faculty expert for an estimate of the amount of P30 discount that you will be able to apply to your study. “Fees” include supplies and equipment maintenance and are charged either per sample, per experiment, or per hour as indicated. All rates are rounded to the nearest dollar.

Contact: Daniel Michele, PhD ([email protected])

Ultrasound Imaging

Core Charges (non-members): $101/hr + $27 (fees)
P30 Member Cost: $27 (fees)

Laser Doppler imaging

Core Charges (non-members): $58/hr + $18/hr (fees)
P30 Member Cost: $18/hr (fees)

Non-invasive blood pressure

Core Charges (non-members): $58/hr + $40/session (fees)
P30 Member Cost: $40/session (fees)

Rotorod

Core Charges (non-members): $58/hr + $30/session (fees)
P30 Member Cost: $30/session (fees)

Grip Strength

Core Charges (non-members): $58/hr + $21/session (fees)
P30 Member Cost: $21/session (fees)

Balance Beam

Core Charges (non-members): $58/hr + $35/session (fees)
P30 Member Cost: $35/session (fees)

Open field/Behavior Testing

Core Charges (non-members): $58/hr + $41/session (fees)
P30 Member Cost: $41/session (fees)

Gait Analysis

Core Charges (non-members): $58/hr + $31/session (fees)
P30 Member Cost: $31/session (fees)

Running Wheels

Core Charges (non-members): Inquire
P30 Member Cost: Inquire

Treadmill

Core Charges (non-members): $58/hr + $30/session (fees)
P30 Member Cost: $30/session (fees)

Training on any of above

Core Charges (non-members): $58/hr
P30 Member Cost: No Cost

Contact: Daniel Michele, PhD ([email protected])

Alzet minipumps

Core Charges (non-members): $21/implant + user supplies
P30 Member Cost: User supplies only

Catheter

Core Charges (non-members): $102/hr
P30 Member Cost: $44/hr

Custom microsurgery

Core Charges (non-members): $102/hr
P30 Member Cost: $44/hr

Blood collection

Core Charges (non-members): $58/hr + $5.82/sample (fees)
P30 Member Cost: $5.82/sample (fees)

Myotoxin muscle regeneration

Core Charges (non-members): $58/hr + User supplies
P30 Member Cost: User supplies only

Telemetry monitoring

Core Charges (non-members): Inquire
P30 Member Cost: Inquire

Trainining on any of above

Core Charges (non-members): $58/hr
P30 Member Cost: $58/hr

Contact: Susan Brooks, PhD ([email protected]) or Dennis Claflin, PhD ([email protected])

Isolated muscle mechanics (includes 3-4 muscles)

Core Charges (non-members): $131/animal + $18/animal (fees)
P30 Member Cost: $18/animal (fees)

Permeabilized fiber training and consultation

Core Charges (non-members): $98/hr
P30 Member Cost: No charge

Permeabilized fiber mechanics by staff

Core Charges (non-members): $146/fiber
P30 Member Cost: $146/fiber

Contacts: Susan Brooks, PhD ([email protected]) or Daniel Michele, PhD ([email protected])

Support for the mechanical testing of soft tissues like tendon, ligament, and cartilage can be conducted by contacting Andy Poli who manages operations in Dr. Arruda's Lab.

Many resources focus on ovine biomechanical testing including bone-to-bone testing of knee ligaments as well as scapula-to-humerus fixtures for investigation of tissues in the rotator cuff group. Imaging can be performed up to 5,400 frames per second and testing combined with digital image correlation has been used recently to examine the biomechanics of native anterior cruciate ligament (ACL), native patellar tendon (PT), and various types of ACL replacement grafts. A transparent saline bath can be used in some tests. Ramped and oscillatory excitations can be applied to soft tissues at speeds of 0-100 mm/s with forces from about 10 mN to 10 kN. A high-speed electric linear actuator is available for speeds near 1000 mm/s. For even higher strain-rate testing, multiple split Hopkinson pressure bars (SHPB) are available.

Hourly support for staff is provided by the P30 so that some biomechanical testing services can be provided free of charge. Standard fixturing for test protocols are available for routine testing, however if custom holders are required, users will be asked to contribute to fabrication or purchasing costs.

Contact: Ken Kozloff, PhD ([email protected])

Support for the mechanical testing of bone tissues can be conducted by contacting Dr. Kozloff. Resources focus on rodent biomechanical testing and tests are typically performed in tandem with samples that have been imaged by microCT or nanoCT cores to provide a fully comprehensive functional phenotype. We encourage users to consider both CT imaging and biomechanical testing on the same samples.

Typical services are shown below:

Whole bone bending Mouse/rat Femur/tibia

Typical Application: Assessment of genetic, mechanical, hormonal perturbation
Tanden Services: In vivo/Ex vivo microCT or nanoCT
Additional Notes: Ex vivo samples must be fresh-frozen, non-fixed, stored at -20°C in hydrated condition

Vertebral body compression Mouse/rat Lumbar/tail

Torsion testing Mouse/rat Long bone

Typical Application: Typically used to assess biomechanics during fracture healing
Tanden Services: Surgical models core. In vivo/Ex vivo microCT or nanoCT
Additional Notes: Ex vivo samples must be fresh-frozen, non-fixed, stored at -20°C in hydrated condition

Tissue-level nanoindentation Mouse/rat Long bone

Typical Application: Used to characterize tissue-level mechanics
Tanden Services: Whole-bone biomechanical testing
Additional Notes: Typically performed after whole bone biomechanics and microCT suggests material property changes

In vivo bone loading

Typical Application: Induce adaptational responses to anabolic signals or repair responses
Tanden Services: In vivo / ex vivo microCT
Additional Notes: Ex vivo samples must be fresh-frozen, non-fixed, stored at -20°C in hydrated condition

Hourly support for staff is provided directly by the P30, and standard biomechanical testing services are provided free of charge. Standard fixturing for test protocols are available for routine testing, however if custom holders are required, users will be asked to contribute to fabrication or purchasing costs. Nanoindentation is permitted for trained users following discussion with the core directors.

Contact: Ken Kozloff, PhD ([email protected])

A fully operational small animal surgical suite is housed within the Orthopaedic Research Laboratories and located within the BSRB animal housing unit. The role of this facility will be to provide services to P30 members seeking metabolic challenge to the skeleton, specifically in the form of bone repair. Surgical models include mouse tibial fracture, drill hole defects, and rat critical defect models. Please contact Dr. Kozloff for support of surgical models.

Bone Surgical Models

Procedure: Fracture, Drill Hole, Critical Defect
Core Charges (non-members): TBD*
P30 Member Cost: TBD*

*A recharge rate is pending. Please contact Dr. Kozloff for inquiries about surgical models.