Animal Modeling Core
Novel murine models for in vivo discovery
The Animal Modeling Core (AMC) facilitates the development and use of state-of-the-art mouse models in skin-related research and provides relevant consultation, training, and troubleshooting for members of the Center interested in pursuing skin-related studies in mice.
Services
Consultation
The AMC supplies consultation for:
- Design and development of project-specific Genetically Engineered Mouse Models (GEMMs), including conventional, Cre-inducible, doxycycline-inducible, and conditional mutant mice.
- Production and validation of mouse models, including transgene construction, verification, genotyping, and GEMM production; screening; breeding, strain establishment, and validation.
Training
The AMC supplies training in:
- In vivo manipulation, including transgene induction protocols, UV irradiation, induction of skin inflammation by exogenous agents, bleomycin-induced fibrosis, and orthotopic xenografts and allografts.
- GEMM phenotyping, including proper tissue collection and processing; morphologic, biochemical, and molecular characterization; cross-species validation.
- Establishment of GEMM-derived primary cultures and immortalized cell lines, taking into consideration key experimental variables including body site, gender, and age.
For current AMC Service Recharge rates, please email [email protected].
Directors
Andrzej A Dlugosz, MD
Associate Chair, Department of Dermatology
Associate Director for Basic Science, Rogel Cancer Center
Professor of Dermatology and Professor of Cell and Developmental Biology
Medical School
J Michelle Kahlenberg MD, PhD
Associate Chair, Department of Internal Medicine
Professor of Internal Medicine and Professor of Dermatology
Medical School
Sunny Y Wong, PhD
Professor of Cell and Development Biology
Medical School
Research Acknowledgement
It is extremely important that our grant is cited in all publications resulting from the use of UM-SBDRC services and funding. Our productivity and effectiveness as a center are measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:
This work utilized Core Services and Pilot or Feasibility project funding supported by grant UM-SBDRC 1P30AR075043 of NIH/NIAMS to the University of Michigan.
