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Forbes Institute for Cancer Discovery
Pharmacokinetics
Advancing discovery of how the body processes drugs
The mission of the University of Michigan Rogel Cancer Center's Pharmacokinetics Shared Resource is to facilitate both preclinical and clinical pharmacokinetic-based cancer research efforts through a range of services to help advance discovery:
- Discover new medicines
- Obtain research funding
- File patent applications
- Publish academic research findings
Pharmacokinetics Objectives
Our pharmacokinetics team studies molecular ADME (absorption, distribution, metabolism, and excretion) and pharmacokinetics of drugs with three objectives:
- To support preclinical pharmacokinetics, drug metabolism and LC-MS analysis for lead compound selection and dose optimization in anticancer drug discovery and development
- To support clinical pharmacokinetics (Non-GLP), LC-MS analysis and dose optimization for clinical trials of anticancer drugs
- To enhance joint grant applications, joint publications and joint patent applications with Rogel Cancer Center members in pharmacokinetic (PK) studies
Service Highlights
- Access to state-of-the-art instrumentation for bioanalysis and MS imaging operated by highly-trained technicians
- Support for drug metabolism and PK of 2600 compounds for drug discovery and development since inception
- Six patents and $15M in grant funding from joint grant applications with Rogel Cancer Center members
- Free consultation for Rogel Cancer Center members
If you have questions about pharmacokinetics services, please contact our team:
Director: Duxin Sun, PhD
Co-Director: Amit Pai, PharmD
Manager: Bo Wen, PhD
Location: NCRC, Bldg 520, 3400
Phone: 734-615-3470
