Experimental Irradiation

The skilled Experimental Irradiation Shared Resource team at the University of Michigan Rogel Cancer Center provides extensive irradiation services to support research studies. We provide expert experimental irradiation for a range of investigators, including those whose primary interests are not in radiation biology, but who need this tool in support of other efforts, such as the immunosuppression of animals prior to stem cell transplantation through total body irradiation.

With safe and efficient sample exposure, our facility is equipped to perform moderate dose rate gamma irradiation (0.1-4 Gy/min) of cell cultures, tissue specimens or animals as well as low dose rate irradiation (0.05-0.3 Gy/hr) of cell cultures.

• Provides centralized and cost-effective access to highly specialized irradiation resources
• Free consultation with expert staff (each with multiple publications in Radiation Biology)
• Whole body irradiation of small animals
• Targeted radiation of in-vivo tumors
• Irradiation of cultured cells
  • Low dose rate
  • Micro-irradiation
  • High-intensity x-ray
• Rogel Cancer Center Members receive a 25% discount on orthovoltage use

This state-of-the-art instrument permits cone beam CT and bioluminescence-based image-guided conformal radiation therapy of small animal models as well as stand-alone cone beam CT and bioluminescent imaging. The SARRP is conveniently located in the UM Medical School (3504E ARF). Pricing is $86/ hour (billed in half hour increments). To discuss capabilities or schedule service, please get in touch with David Karnak (Manager) or Meredith Morgan (Director).

Additional specific goals of the Experimental Irradiation Shared Resource include:

• Support studies in the radiation biology of moderate dose rate irradiation of cell cultures and small animals, such as mice, rats and rabbits
• Permit the study of low dose rate irradiation in cell culture
• Facilitate study of the cellular responses to DNA damage using laser microirradiation as a tool