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AI & Machine Learning -
Applications to Complex Genetic Diseases -
4D Nucleome -
Genomics, Gene Regulation & Epigenomics -
Multi-“omics” Integrative Bioinformatics -
Protein Structure, Proteomics & Alternative Splicing -
Systems Biology & Networks Analysis -
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Software & Bioinformatics Tools
Applications to Complex Genetic Diseases
Many human diseases are linked to genetic dysfunctions. DCMB faculty collaborate with human genetics experts to:
Identify foundational knowledge gaps and develop innovative bioinformatics and computational biology theories and AI and Machine Learning methods to address these.
Test and refine existing theories and AI and Machine Learning methods in bioinformatics and computational medicine toward the study of genetic diseases.
Develop new AI and Machine Learning methods and computational tools for diagnostics and treatments.
The diseases that DCMB/CCMB faculty members study include:
- Alzheimer’s Disease (Guan)
- Amyotrophic Lateral Sclerosis - ALS (Boyle, Karnovsky, Sartor)
- Ataxia (Burmeister)
- Cancers (Baladandayuthapani, Guan, Kitzman, Omenn, Rajapakse, Sartor, Taylor)
- Heart and Brain Health (Wang)
- Mental disorders (Athey, Burmeister)
- Metabolic diseases and obesity (Speliotes)
- Renal diseases (Kretzler)
- Skin diseases (Tsoi)
- Substance Use Disorders - SUD (Burmeister, Athey)
- Type 2 Diabetes - T2D (Parker)
This research overlaps with the study of 4D Nucleome.
Associated Faculty
Brian D Athey, PhD
Michael Savageau Legacy Professor
Chair, Department of Computational Medicine and Bioinformatics
Professor of Computational Medicine and Bioinformatics
Professor of Psychiatry
Medical School
Chair, Department of Computational Medicine and Bioinformatics
Professor of Computational Medicine and Bioinformatics
Professor of Psychiatry
Medical School
Margit Burmeister, PhD
Associate Chair, Department of Computational Medicine and Bioinformatics
Program Director, Bioinformatics Graduate Program
Professor of Human Genetics
Professor of Psychiatry
Research Professor, Michigan Neuroscience Institute and Professor of Computational Medicine and Bioinformatics
Medical School
Program Director, Bioinformatics Graduate Program
Professor of Human Genetics
Professor of Psychiatry
Research Professor, Michigan Neuroscience Institute and Professor of Computational Medicine and Bioinformatics
Medical School
Yuanfang Guan, PhD
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine, Medical School
Professor of Internal Medicine, Medical School
Veera Baladandayuthapani, PhD
Jeremy M G Taylor Collegiate Professor of Biostatistics
Chair, Department of Biostatistics
Professor of Biostatistics
School of Public Health
Professor of Computational Medicine and Bioinformatics
Medical School
Chair, Department of Biostatistics
Professor of Biostatistics
School of Public Health
Professor of Computational Medicine and Bioinformatics
Medical School
Jacob Kitzman, PhD
Associate Professor of Human Genetics
Associate Chair, Department of Human Genetics
Associate Professor of Computational Medicine and Bioinformatics
Medical School
Associate Chair, Department of Human Genetics
Associate Professor of Computational Medicine and Bioinformatics
Medical School
Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
Medical School
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
Medical School
Lana Garmire, PhD
Adjunct Associate Professor of Computational Medicine and Bioinformatics, Medical School
Associate Professor of Biostatistics, School of Public Health
Associate Professor of Biostatistics, School of Public Health
Rajasree Menon, PhD
Research Scientist
Computational Medicine and Bioinformatics
Medical School
Computational Medicine and Bioinformatics
Medical School
Gilbert S Omenn, MD, PhD
Harold T Shapiro Distinguished University Professor of Medicine
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
Professor of Human Genetics
Medical School
Professor of Environmental Health Sciences
School of Public Health
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
Professor of Human Genetics
Medical School
Professor of Environmental Health Sciences
School of Public Health
Stephen CJ Parker, PhD
Professor of Computational Medicine and Bioinformatics
Professor of Human Genetics, Medical School
Professor of Biostatistics, School of Public Health
Professor of Human Genetics, Medical School
Professor of Biostatistics, School of Public Health
Indika Rajapakse, PhD
Professor of Computational Medicine and Bioinformatics, Medical School
Professor of Mathematics, College of Literature, Science, and the Arts
Professor of Biomedical Engineering, Medical School and College of Engineering
Professor of Mathematics, College of Literature, Science, and the Arts
Professor of Biomedical Engineering, Medical School and College of Engineering
Maureen Sartor, PhD
Co-Director
Bioinformatics Graduate Program
Professor of Computational Medicine and Bioinformatics
Medical School
Professor of Biostatistics
School of Public Health
Bioinformatics Graduate Program
Professor of Computational Medicine and Bioinformatics
Medical School
Professor of Biostatistics
School of Public Health
Elizabeth K Speliotes, MD, PhD, MPH
Keith S Henley M.D. Legacy Professor of Gastroenterology
Professor of Internal Medicine
Professor of Computational Medicine and Bioinformatics
Associate Director
Medical Scientist Training Program (MSTP)
Program Director
Precision Medicine Program
Medical School
Professor of Internal Medicine
Professor of Computational Medicine and Bioinformatics
Associate Director
Medical Scientist Training Program (MSTP)
Program Director
Precision Medicine Program
Medical School
Matthew James O'Meara, PhD
Assistant Professor of Computational Medicine and Bioinformatics, Medical School
Assistant Professor of Medicinal Chemistry, College of Pharmacy
Assistant Professor of Medicinal Chemistry, College of Pharmacy
Jeremy M Taylor, PhD
Professor Emeritus of Biostatistics, School of Public Health
Professor Emeritus of Radiation Oncology, Medical School
Professor Emeritus of Radiation Oncology, Medical School
Lam (Alex) C Tsoi, PhD
Associate Professor of Dermatology
Associate Professor of Computational Medicine and Bioinformatics
Research Associate Professor, Mary H Weiser Food Allergy, Medical School
Research Associate Professor, Biostatistics, School of Public Health
Associate Professor of Computational Medicine and Bioinformatics
Research Associate Professor, Mary H Weiser Food Allergy, Medical School
Research Associate Professor, Biostatistics, School of Public Health
Joshua Welch, PhD
Associate Professor of Computational Medicine and Bioinformatics, Medical School
Associate Professor of Electrical Engineering and Computer Science, College of Engineering
Associate Professor of Electrical Engineering and Computer Science, College of Engineering
Yue Zhao, PhD
Research Assistant Professor
Computational Medicine and Bioinformatics
Medical School
Computational Medicine and Bioinformatics
Medical School
