Chromatin Accessibility
Equipment in the Epigenomics Core

Identifying accessible regions in the chromatin structure.


ATAC-Seq is a technique used to identify accessible regions in the chromatin structure. This assay uses the transposase capability to “cut and paste” (tagmentation) adapter sequences in open chromatin regions.

The Epigenomics Core can process cells in suspension (FACS sorted or from culture: this requires coordination with the core lab), cryopreserved cells (i.e., stored in a cryoprotectant). We can also process flash-frozen tissues. We normally use 50,000 nuclei per library preparation. Some samples may require prior test/optimization. Please contact [email protected] before submitting your project.

The Epigenomics Core will perform QC on the data generated before transfer to the investigator.

Nuclei Suspension for scATAC-Seq

We can also prepare nuclei suspension for scATAC-Seq. Please contact [email protected] for more information. (Please note: this will require coordination with the Epigenomics Core lab and the Advanced Genomics Core).

Contact Us
Room C568
Medical Science Research Building (MSRB) II
1150 West Medical Center Drive
Ann Arbor, MI 48109
Phone:: 734-615-1332
About Us
The Epigenomics Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.