Microscopy Core
Photo of a researcher in front of computers showing light microscopy

Offering state-of-the-art microscopy instrumentation and services to support our researchers. 

The Microscopy Core offers support and training on a variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, as well as a wide range of sample preparation services for electron microscopy, and training and assistance with image analysis. 

How We Serve Your Research Needs
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Light Microscopy

The Microscopy Core houses a wide range of light microscopes and imaging systems. These instruments support a variety of imaging modalities.

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Electron Microscopy

The Microscopy Core owns a basic transmission electron microscope (TEM) and scanning electron microscope (SEM) that are suitable for a large majority of biological EM imaging applications.

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Image Analysis

In addition to Light Microscopy and Electron Microscopy services, the Microscopy Core provides researchers support across a variety of open-source and commercial image analysis software packages.

Open Source Software:

Commercial Software:

Almost any feature or quality that can be imagined, such as number, size, shape, or intensity, can potentially be measured. Common image analysis requests include: Multi-channel Segmentation, Object Counting, Object Tracking, and 3D Rendering and Visualization. 

If you are interested in image analysis, guidance, or education, please contact us.

Our Rates

Rates and fees for routine services are listed below. For complex projects that require extensive labor, please consider including core staff as key personnel on grant submissions. Contact us with any questions you may have.

Rates are subject to change following Office of Financial Analysis review.

DeviceInternal PeakInternal Off-PeakOvernightExternal AcademicExternal Industry
JEOL JEM-1400+ LaB6 Transmission Electon Microscope$40/hr$32/hrN/A$56/hr$64/hr
Leica Stellaris 5 Confocal Microscope$40/hr$32/hr$10/hr$56/hr$64/hr
Leica SP8 Confocal with 2-Photon or FLIM$40/hr$32/hr$10/hr$56/hr$64/hr
Leica EM UC7 Ultramicrotome*$25/hr$25/hrN/A$35/hr$40/hr
Leica Upright SP5 Confocal Microscope with 2-Photon$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon A1 Confocal$30/hr$22/hrN/A$42/hr$48/hr
Nikon Ti2 Widefield$22/hr$16/hr$5/hr$32/hr$36/hr
Nikon N-SIM Super Resolution$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa X1 Spinning Disk Confocal$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa W1 SoRa Spinning Disk Confocal $40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss EVO 15 LaB6 Scanning Electron Microscope$40/hr$32/hrN/A$56/hr$64/hr
Zeiss 980 LSCM with AiryScan - Installed April 2023$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Gaussian Lightsheet 7$40/hr$30/hr$10/hr$54/hrN/A
Zeiss Lattice Lightsheet 7$40/hr$30/hr$10/hr$54/hrN/A

Peak times are Monday - Friday, 8:00 am – 6:00 pm.  All other times are Off-Peak. For overnight time lapse experiments over 12 hours only, the time between 12:00 am and 8:00 pm will be charged at the overnight rate. Please inquire regarding the cost and scheduling for time lapse experiments lasting more than 24 hours.

*Skilled users can use an ultramicrotome if they bring their own diamond knife. Training in ultramicrotomy is not typically provided, but could be offered to interested users and would be charged at the labor rate.

ServiceInternalExternal AcademicExternal Industry
Training Per Hour Charge*$75$105$120
Electron Microscopy Sample Preparation (up to 4 samples)$405$567$648
Advanced Electron Microscopy Sample Preparation (up to 4 samples)$955$1,337$1,528
Ultramicrotome Sectioning: Mesh Grids (per sample)$150$210$240
Ultramicrotome Sectioning: Slotted Grids (per sample)$200$280$320
Ultramicrotome Re-sectioning (per block)$75N/AN/A
Critical Point Dryer Per Use Charge$100$140$160
Glow Discharger Per Use Charge$50$70$80
Additional EM Labor Per Hour Charge*$75$105$120
Clearing / Expansion Sample Prep (per sample)$100$140$160
Life Canvas Per Use Charge (excludes reagents)$50$70$80
Additional LM Labor Per Hour Charge*$75$105$120

*Training is charged at the instrument rate plus the labor rate. Training time is estimated at 2 hours for widefield and EM operation and 3 hours for confocal and advanced light microscopy techniques. These training times are only estimates; more or less time may be required. For the Zeiss LLS7, standard training is not typically offered. A labor charge equivalent to 0.5-1 hour will be added to each experiment for assistance with setup. After several experiments, the user may be permitted to set up their own experiment, at which time the labor charge will be waived. Any service not specified in the rate table, including data analysis services, will be charged at the labor rate.

Learning & Outreach

The Microscopy Core offers resources and workshops to support researchers with image analysis and microscopy. Future events will be added as they are offered. Researchers can also find self-guided resources and presentations from past lectures below. 

Our Leadership
Photo of Jennifer Peters, Phd Jennifer Peters, PhD
Managing Director, Microscopy Core
Contact Us
Microscopy Core
Biomedical Research Core Facilities

Biomedical Science Research Building
109 Zina Pitcher Drive, Room A830

North Campus Research Complex
2800 Plymouth Rd, Room 53S

Medical Sciences II
1137 Catherine St, Room 5631 

About Us

The Microscopy Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.

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Join e-HAIL for a discussion on AI-powered approaches and tools to improve mental health for individuals and at scale. At this interactive session, U-M researchers will briefly present some current “mental health & AI” projects, focusing on new collaborations and ways to utilize additional data sources as they become available. This will be followed by table discussions focused on different topics, including topics from the showcase and other topics/problems/innovations that participants are interested in exploring.
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This course will introduce the basics of conducting human subject research in compliance with federal regulations and institutional practices.
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BRCF Bioinformatics Workshop: Reproducible Computing at the University of Michigan
This multi-day, virtual workshop is for researchers who manage lots of data and/or execute compute-intensive analyses.
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Introduction to eResearch
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Bioinformatics Core Reproducible Computing at U-M
This multi-day, virtual workshop is for researchers who manage lots of data and/or execute compute-intensive analyses.
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Waivers, Alterations, and Alternative Forms of Informed Consent
This course offers an overview of some special situations relating to informed consent. Specifically, waivers and alterations of informed consent, waivers of documentation of informed consent, and obtaining consent from non-English speakers.
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Reporting AEs, ORIOs, and UaPs
This course will identify what constitutes an Adverse Event, ORIO, and Unanticipated Problem and how such events impact risk to subjects. Additionally, the course will review the requirements of reporting such events to the IRB and other entities.
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The Michigan Clinical Research Unit (MCRU) is excited to announce the development of an overnight RN pool to support overnight/extended hours. If you have current or upcoming studies that require overnight RN services in MCRU, contact [email protected] for more information.
FFMI fastPACE spring 2024
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Register Today! FFMI fastPACE Spring Cohort Begins Friday, May 10
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The Clinical Trials Support Office (CTSO) is pleased to announce that Mio Nakamura, MD, MS, Clinical Assistant Professor, Dermatology, has been appointed as the new Associate Medical Director of the Michigan Clinical Trials Support Unit (M-CTSU) and Michigan Clinical Research Unit (MCRU). Dr. Nakamura’s appointment will begin July 1, 2024, and is a 2-year term.