Microscopy Core
Photo of a researcher in front of computers showing light microscopy

Offering state-of-the-art microscopy instrumentation and services to support our researchers. 

The Microscopy Core offers support and training on a variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, as well as a wide range of sample preparation services for electron microscopy, and training and assistance with image analysis. 

How We Serve Your Research Needs
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Light Microscopy

The Microscopy Core houses a wide range of light microscopes and imaging systems. These instruments support a variety of imaging modalities.

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Electron Microscopy

The Microscopy Core owns a basic transmission electron microscope (TEM) and scanning electron microscope (SEM) that are suitable for a large majority of biological EM imaging applications.

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Image Analysis

In addition to Light Microscopy and Electron Microscopy services, the Microscopy Core provides researchers support across a variety of open-source and commercial image analysis software packages.

Open Source Software:

Commercial Software:

Almost any feature or quality that can be imagined, such as number, size, shape, or intensity, can potentially be measured. Common image analysis requests include: Multi-channel Segmentation, Object Counting, Object Tracking, and 3D Rendering and Visualization. 

If you are interested in image analysis, guidance, or education, please contact us.

Our Rates

Rates and fees for routine services are listed below. For complex projects that require extensive labor, please consider including core staff as key personnel on grant submissions. Contact us with any questions you may have.

Rates are subject to change following Office of Financial Analysis review.

DeviceInternal PeakInternal Off-PeakOvernightExternal AcademicExternal Industry
JEOL JEM-1400+ LaB6 Transmission Electon Microscope$40/hr$32/hrN/A$56/hr$64/hr
Leica Stellaris 5 Confocal Microscope$40/hr$32/hr$10/hr$56/hr$64/hr
Leica SP8 Confocal with 2-Photon or FLIM$40/hr$32/hr$10/hr$56/hr$64/hr
Leica EM UC7 Ultramicrotome*$25/hr$25/hrN/A$35/hr$40/hr
Leica Upright SP5 Confocal Microscope with 2-Photon$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon A1 Confocal$30/hr$22/hrN/A$42/hr$48/hr
Nikon Ti2 Widefield$22/hr$16/hr$5/hr$32/hr$36/hr
Nikon N-SIM Super Resolution$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa X1 Spinning Disk Confocal$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa W1 SoRa Spinning Disk Confocal $40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss EVO 15 LaB6 Scanning Electron Microscope$40/hr$32/hrN/A$56/hr$64/hr
Zeiss 980 LSCM with AiryScan - Installed April 2023$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Gaussian Lightsheet 7$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Lattice Lightsheet 7$40/hr$32/hr$10/hr$56/hr$64/hr

Peak times are Monday - Friday, 8:00 am – 6:00 pm.  All other times are Off-Peak. For overnight time lapse experiments over 12 hours only, the time between 12:00 am and 8:00 pm will be charged at the overnight rate. Please inquire regarding the cost and scheduling for time lapse experiments lasting more than 24 hours.

*Skilled users can use an ultramicrotome if they bring their own diamond knife. Training in ultramicrotomy is not typically provided, but could be offered to interested users and would be charged at the labor rate.

ServiceInternalExternal AcademicExternal Industry
Training Per Hour Charge*$75$105$120
Electron Microscopy Sample Preparation (up to 4 samples)$405$567$648
Advanced Electron Microscopy Sample Preparation (up to 4 samples)$955$1,337$1,528
Ultramicrotome Sectioning: Mesh Grids (per sample)$150$210$240
Ultramicrotome Sectioning: Slotted Grids (per sample)$200$280$320
Ultramicrotome Re-sectioning (per block)$75N/AN/A
Critical Point Dryer Per Use Charge$100$140$160
Glow Discharger Per Use Charge$50$70$80
Additional EM Labor Per Hour Charge*$75$105$120
Clearing / Expansion Sample Prep (per sample)$100$140$160
Life Canvas Per Use Charge (excludes reagents)$50$70$80
Additional LM Labor Per Hour Charge*$75$105$120

*Training is charged at the instrument rate plus the labor rate. Training time is estimated at 2 hours for widefield and EM operation and 3 hours for confocal and advanced light microscopy techniques. These training times are only estimates; more or less time may be required. For the Zeiss LLS7, standard training is not typically offered. A labor charge equivalent to 0.5-1 hour will be added to each experiment for assistance with setup. After several experiments, the user may be permitted to set up their own experiment, at which time the labor charge will be waived. Any service not specified in the rate table, including data analysis services, will be charged at the labor rate.

Learning & Outreach

The Microscopy Core offers resources and workshops to support researchers with image analysis and microscopy. Future events will be added as they are offered. Researchers can also find self-guided resources and presentations from past lectures below. 

Our Leadership
Photo of Jennifer Peters, Phd Jennifer Peters, PhD
Managing Director, Microscopy Core
Contact Us
Microscopy Core
Biomedical Research Core Facilities

Biomedical Science Research Building
109 Zina Pitcher Drive, Room A830

North Campus Research Complex
2800 Plymouth Rd, Room 53S

Medical Sciences II
1137 Catherine St, Room 5631 

About Us

The Microscopy Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.

Upcoming Research Events All Office of Research Events
FDA Research Involving Drugs and Devices
This course will review what research is subject to FDA oversight, highlight the differences between OHRP and FDA regulations, learn the responsibilities of sponsors, investigators, and the IRB when conducting and reviewing research involving drugs and devices, and examine the requirements for conducting research with a drug or biologic/medical device.
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Not Regulated, Secondary Use, and Umbrella Applications
This course will review the Not Regulated, Secondary Use, and Umbrella application types in eResearch and when these application types are applicable.
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Subparts B, C, and D - Special Populations
This course will examine the additional regulatory requirements for conducting research involving pregnant women, fetuses, neonates, children, and prisoners, including the requirements for these populations in a research project and obtaining informed consent.
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Federal and Institutional Requirements for Human Subject Research
This course will introduce the basics of conducting human subject research in compliance with federal regulations and institutional practices.
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Elements of Informed Consent
This course offers an overview of informed consent in human subject research. The course will examine IRBMED’s standard consent template and focus on how it reflects federal requirements.
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Event Canceled
Advanced Genomics Core and 10x: 2024 Genomics Single Cell and Spatial Symposium
This symposium will be a confluence of ideas and technological insight about how Chromium Single Cell, Visium Spatial, and Xenium In Situ platforms can expand the horizons of your research.
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Introduction to eResearch
This course is intended for those unfamiliar with eResearch, the university’s electronic research administration site. This course will provide a basic knowledge of working in and using eResearch while examining the process for creating and submitting an initial project application.
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Waivers, Alterations, and Alternative Forms of Informed Consent
This course offers an overview of some special situations relating to informed consent. Specifically, waivers and alterations of informed consent, waivers of documentation of informed consent, and obtaining consent from non-English speakers.
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Microscopy Core: Advanced Biological Electron Microscope (EM) Methods Interest Group
The Microscopy Core will be starting an Advanced Biological Electron Microscope (EM) Methods Interest Group. We hope to give U-M scientists with diverse research interests the opportunity to interact and learn from one another, as well as allow us to gauge interest and gather information that will help us in developing core services.
Featured Research News All Office of Research News Photo of an RN sitting with a patient in the MCRU space
Office of Research
New RN Pool Available to Support MCRU Overnight & Extended Hours
The Michigan Clinical Research Unit (MCRU) is excited to announce the development of an overnight RN pool to support overnight/extended hours. If you have current or upcoming studies that require overnight RN services in MCRU, contact [email protected] for more information.
FFMI fastPACE spring 2024
Office of Research
Register Today! FFMI fastPACE Spring Cohort Begins Friday, May 10
Don't miss your chance to participate in this project-based, experiential course designed to help academics launch new innovations, including medical devices/diagnostics, digital solutions, drugs, educational/training interventions, research tools, and many others.
Image of Mio Nakamura, MD, MS
Office of Research
Clinical Trials Support Office Announces New Associate Medical Director
The Clinical Trials Support Office (CTSO) is pleased to announce that Mio Nakamura, MD, MS, Clinical Assistant Professor, Dermatology, has been appointed as the new Associate Medical Director of the Michigan Clinical Trials Support Unit (M-CTSU) and Michigan Clinical Research Unit (MCRU). Dr. Nakamura’s appointment will begin July 1, 2024, and is a 2-year term.