Microscopy Core
Photo of a researcher in front of computers showing light microscopy

Offering state-of-the-art microscopy instrumentation and services to support our researchers. 

The Microscopy Core offers support and training on a variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, as well as a wide range of sample preparation services for electron microscopy, and training and assistance with image analysis. 

How We Serve Your Research Needs
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Light Microscopy

The Microscopy Core houses a wide range of light microscopes and imaging systems. These instruments support a variety of imaging modalities.

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Electron Microscopy

The Microscopy Core owns a basic transmission electron microscope (TEM) and scanning electron microscope (SEM) that are suitable for a large majority of biological EM imaging applications.

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Image Analysis

In addition to Light Microscopy and Electron Microscopy services, the Microscopy Core provides researchers support across a variety of open-source and commercial image analysis software packages.

Open Source Software:

Commercial Software:

Almost any feature or quality that can be imagined, such as number, size, shape, or intensity, can potentially be measured. Common image analysis requests include: Multi-channel Segmentation, Object Counting, Object Tracking, and 3D Rendering and Visualization. 

If you are interested in image analysis, guidance, or education, please contact us.

Our Rates

Rates and fees for routine services are listed below. For complex projects that require extensive labor, please consider including core staff as key personnel on grant submissions. Contact us with any questions you may have.

Rates are subject to change following Office of Financial Analysis review.

DeviceInternal PeakInternal Off-PeakOvernightExternal
JEOL JEM-1400+ LaB6 Transmission Electon Microscope$40/hr$30/hrN/A$54/hr
Leica Stellaris 5 Confocal Microscope$40/hr$30/hr$10/hr$54/hr
Leica SP8 Confocal with 2-Photon or FLIM$40/hr$30/hr$10/hr$54/hr
Leica EM UC7 Ultramicrotome*$25/hr$25/hrN/A$34/hr
Leica Upright SP5 Confocal Microscope with 2-Photon$40/hr$30/hr$10/hr$54/hr
Nikon A1 Confocal$28/hr$21/hrN/A$38/hr
Nikon Ti2 Widefield$20/hr$15/hr$5/hr$27/hr
Nikon N-SIM Super Resolution$40/hr$30/hr$10/hr$54/hr
Nikon X1 Yokogawa Spinning Disk Confocal$40/hr$30/hr$10/hr$54/hr
Retiring Widefields: Nikon E-800 & Zeiss Apotome$20/hr$15/hrN/A$27/hr
Zeiss EVO 15 LaB6 Scanning Electron Microscope$40/hr$30/hrN/A$54/hr
Zeiss 980 LSCM with AiryScan - Installed April 2023$40/hr$30/hr$10/hr$54/hr
Zeiss Gaussian Lightsheet 7$40/hr$30/hr$10/hr$54/hr
Zeiss Lattice Lightsheet 7$40/hr$30/hr$10/hr$54/hr

Peak times are Monday - Friday, 8:00 am – 6:00 pm.  All other times are Off-Peak.  For overnight timelapse experiments over 12 hours only, the time between 12:00 am and 8:00 pm will be charged at the overnight rate. Please inquire regarding the cost and scheduling for timelapse experiments lasting more than 24 hours.

*Skilled users can use an ultramicrotome if they bring their own diamond knife. Training in ultramicrotomy is not typically provided, but could be offered to interested users and would be charged at the labor rate.

Training Per Hour Charge*$75$115
Electron Microscopy Sample Preparation (up to 4 samples)$400$600
Advanced Electron Microscopy Sample Preparation (up to 4 samples)$950$1,425
Ultramicrotome Sectioning: Mesh Grids (per sample)$150$225
Ultramicrotome Sectioning: Slotted Grids (per sample)$200$300
Ultramicrotome Re-sectioning (per block)$75N/A
Critical Point Dryer Per Use Charge$100$150
Glow Discharger Per Use Charge$50$75
Additional EM Labor Per Hour Charge*$75$115
Clearing / Expansion Sample Prep (per sample)$100$150
Life Canvas Per Use Charge (excludes reagents)$50$75
Additional LM Labor Per Hour Charge*$75$115

*Training is charged at the instrument rate plus the labor rate. Training time is estimated at 2 hours for widefield and EM operation and 3 hours for confocal and advanced light microscopy techniques. These training times are only estimates; more or less time may be required. For the Zeiss LLS7, standard training is not typically offered. A labor charge equivalent to 0.5-1 hour will be added to each experiment for assistance with setup. After several experiments, the user may be permitted to set up their own experiment, at which time the labor charge will be waived. Any service not specified in the rate table, including data analysis services, will be charged at the labor rate.

Learning & Outreach

The Microscopy Core offers resources and workshops to support researchers with image analysis and microscopy. Future events will be added as they are offered. Researchers can also find self-guided resources and presentations from past lectures below. 

Our Leadership
Photo of Jennifer Peters, Phd Jennifer Peters, PhD
Managing Director, Microscopy Core
Contact Us
Microscopy Core
Biomedical Research Core Facilities

Biomedical Science Research Building
109 Zina Pitcher Drive, Room A830

North Campus Research Complex
2800 Plymouth Rd, Room 53S

Medical Sciences II
1137 Catherine St, Room 5631 

About Us

The Microscopy Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.

Upcoming Research Events All Office of Research Events
FDA Research Involving Drugs and Devices
This course will review what research is subject to FDA oversight, highlight the differences between OHRP and FDA regulations, learn the responsibilities of sponsors, investigators, and the IRB when conducting and reviewing research involving drugs and devices, and examine the requirements for conducting research with a drug or biologic/medical device.
BRCF Flow Cytometry: Eppendorf Automation Workshop
Streamline your BRCF Flow Cytometry sample preparation with epMotion.
Samples being prepped.
FDA Regulation of Cardiovascular Medical Devices
This webinar will discuss FDA regulation of cardiovascular medical devices.
Not Regulated, Secondary Use, Umbrella Applications
This course will review the Not Regulated, Secondary Use, and Umbrella application types in eResearch and when these application types are applicable.
Central Biorepository Open House
The Central Biorepository (CBR) has recently expanded and upgraded its biospecimen storage space. To showcase the newly renovated facility, the CBR invites you to an upcoming Open House.
Subparts B, C, and D - Special Populations
This course will examine the additional regulatory requirements for conducting research involving pregnant women, fetuses, neonates, children, and prisoners, including the requirements for these populations in a research project and obtaining informed consent.
BRCF Celebrates Elizabeth Hughes' Retirement
You're invited to join the BRCF as we wish Elizabeth Hughes, Interim Managing Director of our Transgenic Animal Model Core (TAMC), a happy retirement following more than 20 years of dedicated service.
Guests at a reception in the atrium at BSRB
Health AI Ethics and Policy Symposium (an e-HAIL joint event)
The Michigan Institute for Data Science (MIDAS), the Learning Health System Collaboratory, the E-Health and Artificial Intelligence (e-HAIL) program and Trust, Innovation and Ethics Research for Responsible AI (TIERRA) invite you to a joint mini-symposium featuring prominent speakers from the U.S. and Canada to explore ethical issues and regulations of health AI.
Audience at an event in the Kahn Auditorium
BRCF Epigenomics Core: Epigenetic Profiling with Illumina: From Arrays to Sequencing
Learn how Illumina technologies can support your epigenetic research through discovery, development, and genetic screening applications.
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Featured Research News All Office of Research News a closeup image of a laptop
Office of Research
Information Assurance Guidelines for Using Applications and Technologies in Research
Before seeking approval for a research project, it is crucial to ensure that the work complies with Information Assurance guidelines.
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Office of Research
Call for R01 Boot Camp Mentees and Coaches
R01 Boot Camp is an intensive mentorship program designed to help early career faculty receive their first NIH Research Project Grants (R01, or equivalent). While developing proposals over the 9-month course, mentees attend a variety of workshops on topics such as grant writing, budgeting, and constructing components of the grant application.
Dr. Prasov and one of his team members in the lab
Office of Research
Research Scouts Program Closes First Year of Funding
Research Scouts supports the Bold Science area of the Medical School's strategic research plan, "Great Minds, Greater Discoveries." The program makes awards of up to $150,000 to novel and visionary projects, and recently closed it's first year of funding.