Microscopy Core
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Offering state-of-the-art microscopy instrumentation and services to support our researchers. 

About the Microscopy Core

 

The Microscopy Core offers support and training on a variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, as well as a wide range of sample preparation services for electron microscopy, and training and assistance with image analysis. 

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Microscopy Core NCRC Open House

We’d love for you to come see our recent renovations!

How We Serve Your Research Needs
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Light Microscopy

The Microscopy Core houses a wide range of light microscopes and imaging systems. These instruments support a variety of imaging modalities.

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Electron Microscopy

The Microscopy Core owns a basic transmission electron microscope (TEM) and scanning electron microscope (SEM) that are suitable for a large majority of biological EM imaging applications.

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Image Analysis

In addition to Light Microscopy and Electron Microscopy services, the Microscopy Core provides researchers support across a variety of open-source and commercial image analysis software packages.

Open Source Software:

Commercial Software:


Almost any feature or quality that can be imagined, such as number, size, shape, or intensity, can potentially be measured. Common image analysis requests include: Multi-channel Segmentation, Object Counting, Object Tracking, and 3D Rendering and Visualization. 

If you are interested in image analysis, guidance, or education, please contact us.

Our Rates

Rates and fees for routine services are listed below. For complex projects that require extensive labor, please consider including core staff as key personnel on grant submissions. Contact us with any questions you may have.

Rates are subject to change following Office of Financial Analysis review.

DeviceInternal PeakInternal Off-PeakOvernightExternal AcademicExternal Industry
JEOL JEM-1400+ LaB6 Transmission Electon Microscope$40/hr$32/hrN/A$56/hr$64/hr
Leica Stellaris 5 Confocal Microscope$40/hr$32/hr$10/hr$56/hr$64/hr
Leica SP8 Confocal with 2-Photon or FLIM$40/hr$32/hr$10/hr$56/hr$64/hr
Leica EM UC7 Ultramicrotome*$25/hr$25/hrN/A$35/hr$40/hr
Leica Upright SP5 Confocal Microscope with 2-Photon$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon A1 Confocal$30/hr$22/hrN/A$42/hr$48/hr
Nikon Ti2 Widefield$22/hr$16/hr$5/hr$32/hr$36/hr
Nikon N-SIM Super Resolution$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa X1 Spinning Disk Confocal$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa W1 SoRa Spinning Disk Confocal $40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss EVO 15 LaB6 Scanning Electron Microscope$40/hr$32/hrN/A$56/hr$64/hr
Zeiss 980 LSCM with AiryScan - Installed April 2023$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Gaussian Lightsheet 7$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Lattice Lightsheet 7$40/hr$32/hr$10/hr$56/hr$64/hr


Peak times are Monday - Friday, 8:00 am – 6:00 pm.  All other times are Off-Peak. For overnight time lapse experiments over 12 hours only, the time between 12:00 am and 8:00 pm will be charged at the overnight rate. Please inquire regarding the cost and scheduling for time lapse experiments lasting more than 24 hours.

*Skilled users can use an ultramicrotome if they bring their own diamond knife. Training in ultramicrotomy is not typically provided, but could be offered to interested users and would be charged at the labor rate.

ServiceInternalExternal AcademicExternal Industry
Training Per Hour Charge*$75$105$120
Electron Microscopy Sample Preparation (up to 4 samples)$405$567$648
Advanced Electron Microscopy Sample Preparation (up to 4 samples)$955$1,337$1,528
Ultramicrotome Sectioning: Mesh Grids (per sample)$150$210$240
Ultramicrotome Sectioning: Slotted Grids (per sample)$200$280$320
Ultramicrotome Re-sectioning (per block)$75N/AN/A
Critical Point Dryer Per Use Charge$100$140$160
Glow Discharger Per Use Charge$50$70$80
Additional EM Labor Per Hour Charge*$75$105$120
Clearing / Expansion Sample Prep (per sample)$100$140$160
Life Canvas Per Use Charge (excludes reagents)$50$70$80
Additional LM Labor Per Hour Charge*$75$105$120


*Training is charged at the instrument rate plus the labor rate. Training time is estimated at 2 hours for widefield and EM operation and 3 hours for confocal and advanced light microscopy techniques. These training times are only estimates; more or less time may be required. For the Zeiss LLS7, standard training is not typically offered. A labor charge equivalent to 0.5-1 hour will be added to each experiment for assistance with setup. After several experiments, the user may be permitted to set up their own experiment, at which time the labor charge will be waived. Any service not specified in the rate table, including data analysis services, will be charged at the labor rate.

Learning & Outreach

The Microscopy Core offers resources and workshops to support researchers with image analysis and microscopy. Future events will be added as they are offered. Researchers can also find self-guided resources and presentations from past lectures below. 

Our Leadership
Photo of Jennifer Peters, Phd Jennifer Peters, PhD
Managing Director, Microscopy Core
Questions?
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Microscopy Core
Biomedical Research Core Facilities

Biomedical Science Research Building
109 Zina Pitcher Drive, Room A830

North Campus Research Complex
2800 Plymouth Rd, Room 53S

Medical Sciences II
1137 Catherine St, Room 5631 

About Us

The Microscopy Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.

Upcoming Research Events All Office of Research Events
Amendments and Continuing Reviews
This course is a follow-up to Initial Project Applications and will examine the process for submitting amendments and scheduled continuing reviews to IRBMED using eResearch once a project’s initial application has been approved.
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Data and Safety Monitoring Boards and Data Safety Monitoring Plans
This course will review when studies are required to have a DSMP or DSMB and how to develop an appropriate DSMP. A DSMB is an independent group that advises the study team regarding subject safety, study conduct, and efficacy. The DSMB will also make recommendations concerning the continuation, modification, or termination of the trial. A DSMP outlines how subject safety and data integrity will be maintained to ensure the validity of collected data.
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Microscopy Core: Advanced Biological EM Methods Interest Group
Learn About Advanced Electron Microscopy (EM) Methods.
A close up of a microscope's eye pieces.
Storage and Retention of Data
This course will review the fundamentals of maintaining confidentiality of subject data, including data encryption and protection, using secure environments and external websites, and distinguishing among anonymized, coded, and de- identified datasets.
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Bioinformatics Core Summer Workshop Series
Composed of the two companion workshops (Computational Foundations and RNA-Seq Demystified), this virtual workshop series is for researchers who would like to better understand the analysis of differential gene expression in bulk RNA-Seq data.
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Introduction to sIRBs
This course will identify the Single IRB model for Multi-Site research, show the regulatory requirements of sIRB review and the exceptions to sIRB requirements, and explain sIRB requests of IRBMED as sIRB (accepting oversight), External IRB as sIRB (ceding oversight), and UofM as the Coordinating Center.
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Flow Cytometry Core FlowJo™ Software Training
Learn how to use the FlowJo™ workspace, including how to load files, evaluate sample quality, draw gates, generate tabular and graphical layouts, and perform compensation. Designed for those new to the software or need a refresher.
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Microscopy Core: Advanced Biological EM Methods Interest Group
Learn About Advanced Electron Microscopy (EM) Methods.
A close up of a microscope's eye pieces.
FDA Research Involving Drugs and Devices
This course will review what research is subject to FDA oversight, highlight the differences between OHRP and FDA regulations, learn the responsibilities of sponsors, investigators, and the IRB when conducting and reviewing research involving drugs and devices, and examine the requirements for conducting research with a drug or biologic/medical device.
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Featured Research News All Office of Research News Fun illustration in red, white, and blue, with the words "fourth of July"
Office of Research
Several Cores Closed for the Holiday
In observance of the Independence Day, several cores will have a change in operations.
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Office of Research
New RN Pool Available to Support MCRU Overnight & Extended Hours
The Michigan Clinical Research Unit (MCRU) is excited to announce the development of an overnight RN pool to support overnight/extended hours. If you have current or upcoming studies that require overnight RN services in MCRU, contact [email protected] for more information.
FFMI fastPACE spring 2024
Office of Research
Register Today! FFMI fastPACE Spring Cohort Begins Friday, May 10
Don't miss your chance to participate in this project-based, experiential course designed to help academics launch new innovations, including medical devices/diagnostics, digital solutions, drugs, educational/training interventions, research tools, and many others.