Microscopy Core
Photo of a researcher in front of computers showing light microscopy

Offering state-of-the-art microscopy instrumentation and services to support our researchers. 

The Microscopy Core offers support and training on a variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, as well as a wide range of sample preparation services for electron microscopy, and training and assistance with image analysis. 

How We Serve Your Research Needs
Photo of a male researcher sitting in front of a computer looking at light microscopy imaging
Light Microscopy

The Microscopy Core houses a wide range of light microscopes and imaging systems. These instruments support a variety of imaging modalities.

Learn More
Photo of a researcher in front of computers showing electron microscopy
Electron Microscopy

The Microscopy Core owns a basic transmission electron microscope (TEM) and scanning electron microscope (SEM) that are suitable for a large majority of biological EM imaging applications.

Learn More
Image Analysis

In addition to Light Microscopy and Electron Microscopy services, the Microscopy Core provides researchers support across a variety of open-source and commercial image analysis software packages.

Open Source Software:

Commercial Software:


Almost any feature or quality that can be imagined, such as number, size, shape, or intensity, can potentially be measured. Common image analysis requests include: Multi-channel Segmentation, Object Counting, Object Tracking, and 3D Rendering and Visualization. 

If you are interested in image analysis, guidance, or education, please contact us.

Our Rates

Rates and fees for routine services are listed below. For complex projects that require extensive labor, please consider including core staff as key personnel on grant submissions. Contact us with any questions you may have.

Rates are subject to change following Office of Financial Analysis review.

DeviceInternal PeakInternal Off-PeakOvernightExternal AcademicExternal Industry
JEOL JEM-1400+ LaB6 Transmission Electon Microscope$40/hr$32/hrN/A$56/hr$64/hr
Leica Stellaris 5 Confocal Microscope$40/hr$32/hr$10/hr$56/hr$64/hr
Leica SP8 Confocal with 2-Photon or FLIM$40/hr$32/hr$10/hr$56/hr$64/hr
Leica EM UC7 Ultramicrotome*$25/hr$25/hrN/A$35/hr$40/hr
Leica Upright SP5 Confocal Microscope with 2-Photon$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon A1 Confocal$30/hr$22/hrN/A$42/hr$48/hr
Nikon Ti2 Widefield$22/hr$16/hr$5/hr$32/hr$36/hr
Nikon N-SIM Super Resolution$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa X1 Spinning Disk Confocal$40/hr$32/hr$10/hr$56/hr$64/hr
Nikon Yokogawa W1 SoRa Spinning Disk Confocal $40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss EVO 15 LaB6 Scanning Electron Microscope$40/hr$32/hrN/A$56/hr$64/hr
Zeiss 980 LSCM with AiryScan - Installed April 2023$40/hr$32/hr$10/hr$56/hr$64/hr
Zeiss Gaussian Lightsheet 7$40/hr$30/hr$10/hr$54/hrN/A
Zeiss Lattice Lightsheet 7$40/hr$30/hr$10/hr$54/hrN/A


Peak times are Monday - Friday, 8:00 am – 6:00 pm.  All other times are Off-Peak. For overnight time lapse experiments over 12 hours only, the time between 12:00 am and 8:00 pm will be charged at the overnight rate. Please inquire regarding the cost and scheduling for time lapse experiments lasting more than 24 hours.

*Skilled users can use an ultramicrotome if they bring their own diamond knife. Training in ultramicrotomy is not typically provided, but could be offered to interested users and would be charged at the labor rate.

ServiceInternalExternal AcademicExternal Industry
Training Per Hour Charge*$75$105$120
Electron Microscopy Sample Preparation (up to 4 samples)$405$567$648
Advanced Electron Microscopy Sample Preparation (up to 4 samples)$955$1,337$1,528
Ultramicrotome Sectioning: Mesh Grids (per sample)$150$210$240
Ultramicrotome Sectioning: Slotted Grids (per sample)$200$280$320
Ultramicrotome Re-sectioning (per block)$75N/AN/A
Critical Point Dryer Per Use Charge$100$140$160
Glow Discharger Per Use Charge$50$70$80
Additional EM Labor Per Hour Charge*$75$105$120
Clearing / Expansion Sample Prep (per sample)$100$140$160
Life Canvas Per Use Charge (excludes reagents)$50$70$80
Additional LM Labor Per Hour Charge*$75$105$120


*Training is charged at the instrument rate plus the labor rate. Training time is estimated at 2 hours for widefield and EM operation and 3 hours for confocal and advanced light microscopy techniques. These training times are only estimates; more or less time may be required. For the Zeiss LLS7, standard training is not typically offered. A labor charge equivalent to 0.5-1 hour will be added to each experiment for assistance with setup. After several experiments, the user may be permitted to set up their own experiment, at which time the labor charge will be waived. Any service not specified in the rate table, including data analysis services, will be charged at the labor rate.

Learning & Outreach

The Microscopy Core offers resources and workshops to support researchers with image analysis and microscopy. Future events will be added as they are offered. Researchers can also find self-guided resources and presentations from past lectures below. 

Our Leadership
Photo of Jennifer Peters, Phd Jennifer Peters, PhD
Managing Director, Microscopy Core
Questions?
Contact Us
Microscopy Core
Biomedical Research Core Facilities

Biomedical Science Research Building
109 Zina Pitcher Drive, Room A830

North Campus Research Complex
2800 Plymouth Rd, Room 53S

Medical Sciences II
1137 Catherine St, Room 5631 

About Us

The Microscopy Core is one of the Biomedical Research Core Facilities, and a part of the Medical School Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the Michigan Medicine research community and supports biomedical science from insight to impact.

Upcoming Research Events All Office of Research Events
Opportunities for AI in Mental Health: e-HAIL In-Person Roundtable Conversation
Join e-HAIL for a discussion on AI-powered approaches and tools to improve mental health for individuals and at scale. At this interactive session, U-M researchers will briefly present some current “mental health & AI” projects, focusing on new collaborations and ways to utilize additional data sources as they become available. This will be followed by table discussions focused on different topics, including topics from the showcase and other topics/problems/innovations that participants are interested in exploring.
e-HAIL discussion 23
Federal and Institutional Requirements for Human Subject Research
This course will introduce the basics of conducting human subject research in compliance with federal regulations and institutional practices.
A man participating in a zoom event
Event Rescheduled
BRCF Bioinformatics Workshop: Reproducible Computing at the University of Michigan
This multi-day, virtual workshop is for researchers who manage lots of data and/or execute compute-intensive analyses.
An illustration of a very large laptop and several figures sitting around the edges in a variety of poses.
Elements of Informed Consent
This course offers an overview of informed consent in human subject research. The course will examine IRBMED’s standard consent template and focus on how it reflects federal requirements.
A zoom event on a laptop
Advanced Genomics Core and Singular Genomics: G4 Sequencing Platform and G4XTM Spatial Sequencer
Learn about the G4, a bench-top sequencer with novel high-performance chemistry and advanced engineering, optimized to deliver unmatched power, speed, and flexibility, and the G4XTM Spatial Sequencer, a high-throughput in situ spatial sequencer for transcriptomic and proteomic analysis from FFPE samples at subcellular resolution.
A man listens to a lecture. Others are in the background, also listening to the lecture.
Introduction to eResearch
This course is intended for those unfamiliar with eResearch, the university’s electronic research administration site. This course will provide a basic knowledge of working in and using eResearch while examining the process for creating and submitting an initial project application.
A computer screen showing multiple people participating in a zoom event
Bioinformatics Core Reproducible Computing at U-M
This multi-day, virtual workshop is for researchers who manage lots of data and/or execute compute-intensive analyses.
An illustration of a very large laptop and several figures sitting around the edges in a variety of poses.
Waivers, Alterations, and Alternative Forms of Informed Consent
This course offers an overview of some special situations relating to informed consent. Specifically, waivers and alterations of informed consent, waivers of documentation of informed consent, and obtaining consent from non-English speakers.
A woman participating in a zoom event
Reporting AEs, ORIOs, and UaPs
This course will identify what constitutes an Adverse Event, ORIO, and Unanticipated Problem and how such events impact risk to subjects. Additionally, the course will review the requirements of reporting such events to the IRB and other entities.
A man participating in a zoom event
Featured Research News All Office of Research News Photo of an RN sitting with a patient in the MCRU space
Office of Research
New RN Pool Available to Support MCRU Overnight & Extended Hours
The Michigan Clinical Research Unit (MCRU) is excited to announce the development of an overnight RN pool to support overnight/extended hours. If you have current or upcoming studies that require overnight RN services in MCRU, contact [email protected] for more information.
FFMI fastPACE spring 2024
Office of Research
Register Today! FFMI fastPACE Spring Cohort Begins Friday, May 10
Don't miss your chance to participate in this project-based, experiential course designed to help academics launch new innovations, including medical devices/diagnostics, digital solutions, drugs, educational/training interventions, research tools, and many others.
Image of Mio Nakamura, MD, MS
Office of Research
Clinical Trials Support Office Announces New Associate Medical Director
The Clinical Trials Support Office (CTSO) is pleased to announce that Mio Nakamura, MD, MS, Clinical Assistant Professor, Dermatology, has been appointed as the new Associate Medical Director of the Michigan Clinical Trials Support Unit (M-CTSU) and Michigan Clinical Research Unit (MCRU). Dr. Nakamura’s appointment will begin July 1, 2024, and is a 2-year term.