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Publications | MMPC-Live

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Publications

The list of publications highlights discoveries about how the body and brain work. The studies explore topics like metabolism, obesity, diabetes, brain development, and nerve function. Together, they demonstrate how science enables us to understand health and disease in clearer terms.

Carol F Elias and Nathan Qi (2024)

"MMPC-live: Accessible resources for phenotyping of live mouse models of diabetes and obesity", Open Access Government January 2025, pp.106-107.

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Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model. BioRxiv. 2026 Jan 14:2026.01.13.699318. doi: 10.64898/2026.01.13.699318.

Digital twins for in vivo metabolic flux estimations in patients with brain cancer. Cell Metab. 2026 Jan 6;38(1):228-246.e17. doi:10.1016/j.cmet.2025.10.022. Epub 2025 Dec 1.
Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression. bioRxiv [Preprint]. 2025 Dec 19:2025.12.17.694916. doi: 10.64898/2025.12.17.694916.
Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients. medRxiv [Preprint]. 2025 Nov 13:2025.11.11.25340023.doi: 10.1101/2025.11.11.25340023.
Rewiring of cortical glucose metabolism fuels human brain cancer growth. Nature. 2025 Oct;646(8084):413-422.doi: 10.1038/s41586-025-09460-7. Epub 2025 Sep 3.
Comparing Neuroprotective Drug Efficacy in Rodent Neonatal Brain Injury Models. bioRxiv [Preprint]. 2025 Sep 19:2025.09.17.676833.doi: 10.1101/2025.09.17.676833.
Effects of FGF21, soluble TGFBR2, and environmental temperature on metabolic dysfunction in lipodystrophic mice. JCI Insight. 2025 Jul 15;10(16):e194882.doi: 10.1172/jci.insight.194882. eCollection 2025 Aug 22.
Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition. FASEB J. 2025 Jul 15;39(13):e70755.doi: 10.1096/fj.202500398R.
Neuronal SEL1L-HRD1 ERAD regulates one-carbon metabolism and is essential for motor function and survival. bioRxiv [Preprint]. 2025 Jun 18:2025.06.16.659938.doi: 10.1101/2025.06.16.659938.
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues.
Science. 2025 Apr 11;388(6743):eadf2034. doi: 10.1126/science.adf2034. Epub 2025 Apr 11. PMID: 39913641 PMCID: PMC11985298 DOI: 10.1126/science.adf2034
Loss of CTRP10 results in female obesity with preserved metabolic health.
Chen F, Sarver DC, Saqib M, Velez LM, Aja S, Seldin MM, Wong GW. Elife. 2025 Mar 24;13:RP93373. doi: 10.7554/eLife.93373.
PMID: 40126547 Free PMC article.

Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice.
Torres M, Pederson B, Wang H, Lin LL, Wang HH, Bugarin-Lapuz A, Zhao Z, Qi L. JCI Insight. 2024 Nov 8;9(21):e174725. doi: 10.1172/jci.insight.174725.
PMID: 39352758 Free PMC article.
GDF15 Knockout Does Not Substantially Impact Perinatal Body Weight or Neonatal Outcomes in Mice.
Mulcahy MC, El Habbal N, Redd JR, Sun H, Gregg BE, Bridges D. Endocrinology. 2024 Oct 30;165(12):bqae143. doi: 10.1210/endocr/bqae143.
PMID: 39445824
Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis.
Choi EK, Aring L, Peng Y, Correia AB, Lieberman AP, Iwase S, Seo YA. JCI Insight. 2024 Oct 22;9(20):e168440. doi: 10.1172/jci.insight.168440.
PMID: 39435657 Free PMC article.
Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy.
Eid SA, Elzinga SE, Guo K, Hinder LM, Hayes JM, Pacut CM, Koubek EJ, Hur J, Feldman EL. Transl Res. 2024 Aug;270:24-41. doi: 10.1016/j.trsl.2024.03.009. Epub 2024 Mar 29.
Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice C Sáenz de Miera, N Bellefontaine, SJ Allen, MG Myers Jr., CF Elias | eLife doi: 10.7554/eLife.93204.1. 2024 (Full Publication)
Noise and Vibration Generation and Response of Mice (Mus muculus) to Routine Intrafacility Transportation Methods Jessica R Cordingley, DVM, Jean Nemzek, DVM, MS, DACVS, and Nathan Qi, MD, PhD | JAALAS 2024 (Full Publication)

The Influence of Maternal High Fat Diet During Lactation on Offspring Hematopoietic Priming
Kim K, Varghese M, Sun H, Abrishami S, Bowers E, Bridges D, Meijer JL, Singer K, Gregg B.
Endocrinology. 2023 Nov 20;165(1):bqad182. doi: 10.1210/endocr/bqad182.
PMID: 38048597 Free PMC article.
Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice.
Sáenz de Miera C, Feng J, Elias CF, Qi N. J Vis Exp. 2023 Aug 25;(198):10.3791/65875. doi: 10.3791/65875.
PMID: 37677024 Free PMC article.
Jugular Vein and Carotid Artery Canulation for Automated Blood Sampling in Mice Stereotaxic Delivery of Adeno-Associated Viruses to a Specific Cell Population Linked to Serial Automated Blood Collection
Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a db/db mouse model of type 2 diabetes Stephanie A. Eid, Phillipe D. O'Brien, Katharina H. Kretzler, Dae-Gyu Jang, Faye E. Mendelson, John M. Hayes, Andrew Carter, Hongyu Zhang, Subramaniam Pennathur, Frank C. Brosius III, Emily J. Koubek, Eva L. Feldman | FASEB J. 2023 Aug; 37(8):e23115 (Full Publication)
Mouse Study Hints at Specific Brain Receptor behind PCOS Symptoms Alexandra L Cara, Laura L Burger, Bethany G Beekly, Susan J Allen, Emily L Henson, Richard J Auchus, Martin G Myers, Jr., Suzanne M Moenter and Carol F Elias | Endocrinology. 2023 Mar; 164(3): bqad015
(Full Publication)
Hypermetabolism in mice carrying a near-complete human chromosome 21.
Sarver DC, Xu C, Rodriguez S, Aja S, Jaffe AE, Gao FJ, Delannoy M, Periasamy M, Kazuki Y, Oshimura M, Reeves RH, Wong GW. Elife. 2023 May 30;12:e86023. doi: 10.7554/eLife.86023.
PMID: 37249575 Free PMC article.

Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by β2-adrenergic signaling. Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, Kennedy RT, Maillard I, Ye L, Jun H, Wu J. EMBO J. 2021 Dec 15;40(24):e106061.
Microscopic examination of spatial transcriptome using Seq-Scope. Cho CS, Xi J, Si Y, Park SR, Hsu JE, Kim M, Jun G, Kang HM, Lee JH. Cell. 2021 Jun 24;184(13):3559-3572.
Adult-born POMC neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency. Surbhi (Gahlot S)*, Wittmann G*, Low MJ and Lechan RM. Mol Metab. 2021 Nov;53:101312.
Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment. Hafner H, Mulcahy MC, Carlson Z, Hartley P, Sun H, Westerhoff M, Qi N, Bridges D, Gregg B. Front Nutr. 2021 Dec 15; 8:759690.
Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps. Bruce JIE, Sánchez-Alvarez R, Sans MD, Sugden SA, Qi N, James AD, and Williams JA. Nat Commun. 2021 Jul 19;12(1):4386.
ARCGHR Neurons Regulate Muscle Glucose Uptake. de Lima JBD, Debarba LK, Rupp AC, Qi N, Ubah C, Khan M, Didyuk O, Ayyar I, Koch M, Sandoval DA, and Sadagurski M. Cells. 2021 May 3; 10(5):1093.
Importance of adipose tissue NAD+ biology in regulating metabolic flexibility. Endocrinology. Franczyk MP*, Qi N*, Stromsdorfer KL, Li C, Yamaguchi S, Itoh H, Yoshino M, Sasaki Y, Brookheart RT, Finck BN, DeBosch BJ, Klein S, and Yoshino J. Endocrinology. 2021 Mar 1;162(3):bqab006.

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity. Molecular metabolism. Yu H, Chhabra KH, Thompson Z, Jones GL, Kiran S, Shangguan G, Low MJ. Molecular metabolism. 2020 May;35:100957.
Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice. Gunder LC, Harvey I, Redd JR, Davis CS, Al-Tamimi A, Brooks SV, Bridges D. Biomedicines. 2020 October 15;8(10):420.
Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy. Yu H, Thompson Z, Kiran S, Jones GL, Mundada L, Rubinstein M, Low MJ. J Endocrinol. 2020 April;245(1):115-127.
In vivo glucoregulation and tissue-specific glucose uptake in female Akt substrate 160 kDa knockout rats. Zheng X, Arias EB, Qi NR, Saunders TL, Cartee GD. PLoS One. 2020 Feb 13; 15:e0223340.
Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney. Ann M Laszczyk, Atsuko Y Higashi, Sanjeevkumar R Patel, Craig N Johnson, Abdul Soofi, Saji Abraham, Gregory R Dressler. J Am Soc Nephrol. 2020 Jun;31(6):1212-1225.

Lateral Hypothalamic Mc3R-Expressing Neurons Modulate Locomotor Activity, Energy Expenditure, and Adiposity in Male Mice. Pei H, Patterson CM, Sutton AK, Burnett KH, Myers MG Jr, Olson DP. Endocrinology. 2019 February 1;160(2):343- 358.
The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic β cells and adipocytes. Corsa CAS, Pearson GL, Renberg A, Askar MM, Vozheiko T, MacDougald OA, Soleimanpour SA. J Biol Chem. 2019 May 3;294(18):7296-7307.
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. Flores A, Argetsinger LS, Stadler LKJ, Malaga AE, Vander PB, DeSantis LC, Joe RM, Cline JM, Keogh JM, Henning E, Barroso I, Mendes de Oliveira E, Chandrashekar G, Clutter ES, Hu Y, Stuckey J, Farooqi IS, Myers MG Jr, Carter-Su C. Diabetes. 2019 November;68(11):2049-2062.
Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network. Jones GL, Wittmann G, Yokosawa EB, Yu H, Mercer AJ, Lechan RM, Low MJ. eNeuro. 2019 April 1;6(2):ENEURO.0400-18.
Transcriptional and physiological roles for STAT proteins in leptin action. Pan W, Allison MB, Sabatini P, Rupp A, Adams J, Patterson C, Jones JC, Olson DP, Myers MG Jr. Mol Metab. 2019 April;22:121-131.
Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D. Jarvela TS, Surbhi, Shakya M, Bachor T, White A, Low MJ, Lindberg I. Endocrinology. 2019 November 1;160(11):2630-2645.
Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice. Yamaguchi S, Franczyk MP, Chondronikola M, Qi N, Gunawardana SC, Stromsdorfer KL, Porter LC, Wozniak DF, Sasaki Y, Rensing N, Wong M, Piston DW, Klein S, Yoshino J. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23822-23828.
Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training.Brown LA, Judge JL, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV. Data Brief. 2019 Oct 10; 27:104570.
Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training. Brown LA, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV. Exp Gerontol. 2019 Oct 1;125:110657.
NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. Vendrov AE, Sumida A, Canugovi C, Lozhkin A, Hayami T, Madamanchi NR, Runge MS. Redox Biol. 2019 February;21:101063.
Proline mediates metabolic communication between retinal pigment epithelial cells and the retina.Yam M, Engel AL, Wang Y, Zhu S, Hauer A, Zhang R, Lohner D, Huang J, Dinterman M, Zhao C, Chao JR, Du J. J Biol Chem. 2019 Jun 28;294(26):10278-10289.
Whole body glucoregulation and tissue-specific glucose uptake in a novel Akt substrate of 160 kDa knockout rat model. Arias EB, Zheng X, Agrawal S, Cartee GD. PLoS One. 2019 Apr 29; 14(4):e0216236.
Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice. Tooke BP, Yu H, Adams JM, Jones GL, Sutton-Kennedy T, Mundada L, Qi NR, Low MJ, Chhabra KH. Mol Metab. 2019 Feb; 20:194-204.
Adipose tissue senescence and inflammation in aging is reversed by the young milieu. Ghosh AK, O'Brien M, Mau T, Qi N, Yung R. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1709-1715.
NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase. Stevenson MD, Canugovi C, Vendrov AE, Hayami T, Bowles DE, Krause KH, Madamanchi NR, Runge MS. Antioxidants & redox signaling. 2019 July 1;31(1):39-58.

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. The Journal of clinical investigation. Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L. The Journal of clinical investigation. 2018 March 1;128(3):1125-1140.
Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin. Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Strohbehn G, Trevaskis J, Rhodes CJ, Olson DP, Myers MG Jr. Endocrinology. 2018 April 1;159(4):1860-1872.
Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. Wood L, Roelofs K, Koch LG, Britton SL, Sandoval DA. Molecular metabolism. 2018 May;11:189-196.
Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action. Allison MB, Pan W, MacKenzie A, Patterson C, Shah K, Barnes T, Cheng W, Rupp A, Olson DP, Myers MG Jr. Diabetes. 2018 June;67(6):1093-1104.
Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance. Rupp AC, Allison MB, Jones JC, Patterson CM, Faber CL, Bozadjieva N, Heisler LK, Seeley RJ, Olson DP, Myers MG Jr. Mol Metab. 2018 August;14:130-138.
Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats. Moxley MA, Vinnakota KC, Bazil JN, Qi NR, Beard DA. PLoS Comput Biol. 2018 February;14(2):e1005982.
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T. Nat Commun. 2018 Sep 10; 9(1):3658.
Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice. Harvey I, Stephenson EJ, Redd JR, Tran QT, Hochberg I, Qi N, Bridges D. Endocrinology. 2018 Jun 1;159(6):2275-2287.
Deficiency of the Mitochondrial NAD Kinase Causes Stress-induced hepatic steatosis in mice. Zhang K, Kim H, Fu Z, Qiu Y, Li J, Wu J, Qi NR, Houten SM, Zhang R. Gastroenterology 2018 Jan; 154(1): 224-237.

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and subsequent improvement in glucose tolerance in hypothalamus-specific Pomc knockout mice. Chhabra KH, Morgan DA, Tooke B, Adams JM, Rahmouni K and Low MJ. Mol Metab. 2017, 6:1274-1285.
The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. Soofi A, Wolf KI, Emont MP, Qi N, Martinez-Santibanez G, Grimley E, Ostwani W, Dressler GR. J Biol Chem 292(22): 9051-9062, 2017.
Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG Jr, Miller RA, Sandoval DA, Sadagurski M. Mol Metab. 2017 Mar 16;6(5):393-405.