Mood Disorders Lab

Nurse with mask on setting up an IV

Improving Treatments

We focus on developing and evaluating new interventions to help individuals affected by depression and bipolar disorder.

Research

In the U-M Medical School Department of Psychiatry, we conduct a range of studies on mood disorders, including depression and bipolar disorder. 

Our current, upcoming, and past research activities are designed to discover more effective treatments and improve outcomes for those living with mood disorders.

Contact

If you're interested in participating in research, please contact our team.

Active Studies

COMPASS

This study is designed to assess the safety and efficacy of a synthetic analogue of psilocybin for individuals with treatment-resistant depression. This is a phase 3, multisite, active placebo, randomized, double-blind trial. 

Participants will be enrolled for up to 62 weeks and will receive 2 to 4 dosing sessions with one of three possible doses of COMP360. All dosing is provided with accompanying psychotherapy.

Interventional Psychiatry Registry

This registry aims to better understand the long-term effects of novel clinical interventions for mood disorders, such as ketamine, electroconvulsive therapy (ECT), and transcranial magnetic stimulation (TMS). The study focuses on the durability of treatment efficacy and potential long-term adverse events. 

We are enrolling individuals who receive IV ketamine infusions, TMS, ECT, other novel treatments, or who participate in clinical trials for mood disorders, and will track their treatment progression and psychiatric symptoms over one year.

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Program Leadership
See all Psychiatry faculty portrait of Sagar Parikh

Sagar V Parikh, MD, FRCPC
John F Greden Professor of Depression and Clinical Neuroscience
Professor of Psychiatry
Program Director - Unipolar, Psychiatry, Medical School
Professor of Health Management and Policy, School of Public Health

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